{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The abstract (1) does not provide any information regarding the function of LRP4‐AS1. Instead, it focuses on the prognostic value of circulating tumor cell (CTC) detection and the associated genomic landscape in breast cancer patients with brain metastases. In this study, two enrichment methods for CTCs—an EpCAM‐dependent approach and an EpCAM‐independent Ficoll-based centrifugation—were employed, and their detection rates were correlated with clinical features such as ERBB2 status, bone metastases, and overall survival. In addition, next-generation sequencing analyses of individual CTCs and matched tumor tissues revealed chromosomal aberrations and mutations in pathways potentially related to brain metastasis formation. However, at no point is LRP4‐AS1 mentioned or its function discussed, leaving its role in this context unresolved."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carlotta Riebensahm, Simon A Joosse, Malte Mohme, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clonality of circulating tumor cells in breast cancer brain metastasis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-019-1184-2"}], "href": "https://doi.org/10.1186/s13058-019-1184-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31481116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31481116"}]}]}]}