{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Research in two separate studies has provided insights into the broader genomic region encompassing LRRC2 and its associated long non‐coding RNA, LRRC2‐AS1. In one study examining deletions on chromosome 3p21.3, the LRRC2 gene was identified as part of a complex region (C3CER1) enriched for several novel genes and chemokine receptor clusters with potential tumor suppressor functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although this work focused on the coding gene LRRC2—a relative of the Ras Suppressor Protein 1 (RSP-1)—it establishes the genomic context in which LRRC2‐AS1 is located."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a distinct study investigating neuropsychiatric conditions, LRRC2‐AS1 was characterized as a long non‐coding RNA with altered expression in autism spectrum disorder (ASD). Specifically, LRRC2‐AS1 expression was found to be significantly lower in the peripheral blood of children with ASD compared with that in healthy controls (Posterior Beta = –3.781, P value < 0.0001), and its expression profile provided considerable discriminative power (AUC = 0.92) between ASD cases and controls."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, inverse correlations were identified between LRRC2‐AS1 and several other lncRNAs, suggesting that LRRC2‐AS1 may participate in a broader regulatory network relevant to neurodevelopment."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings imply that while the LRRC2 locus is embedded within a genomic region implicated in tumor suppression, its antisense transcript LRRC2‐AS1 may serve a distinct role in modulating neuropsychiatric phenotypes, potentially acting as a novel epigenetic marker for ASD.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hajnalka Kiss, Ying Yang, Csaba Kiss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5200758"}], "href": "https://doi.org/10.1038/sj.ejhg.5200758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11896456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11896456"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kasra Honarmand Tamizkar, Soudeh Ghafouri-Fard, Mir Davood Omrani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression of lncRNAs in autism spectrum disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Metab Brain Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11011-021-00681-z"}], "href": "https://doi.org/10.1007/s11011-021-00681-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33587235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33587235"}]}]}]}