LRRC53 Gene

Name	leucine rich repeat containing 53
Proteins	LRC53_HUMAN
NCBI Gene ID	100144878
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LRRC53 has 474 functional associations with biological entities spanning 6 categories (disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 15 datasets.

Click the + buttons to view associations for LRRC53 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LRRC53 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with LRRC53 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LRRC53 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LRRC53 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LRRC53 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LRRC53 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	GTEx eQTL 2025	SNPs regulating expression of LRRC53 gene from the GTEx eQTL 2025 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of LRRC53 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of LRRC53 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	HPA Tissue Gene Expression Profiles	tissues with high or low expression of LRRC53 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of LRRC53 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of LRRC53 gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of LRRC53 gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of LRRC53 gene from the RummaGEO Gene Perturbation Signatures dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of LRRC53 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with LRRC53 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.