{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LRRC75A‐AS1 is a long noncoding RNA that appears to function in a context‐dependent manner across different disease types. In several solid tumors such as triple‐negative breast cancer and glioblastoma, LRRC75A‐AS1 acts as an oncogenic factor by serving as a competing endogenous RNA. In these settings, it sponges specific microRNAs (for example, miR‐380-3p in triple‐negative breast cancer and miR‐223-3p in glioblastoma), resulting in the upregulation of oncogenic targets (BAALC and CTNND1, respectively) that promote cell proliferation, invasion, and epithelial–mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, studies in colorectal carcinoma and multiple myeloma indicate that LRRC75A‐AS1 may exert tumor‐suppressive effects, as its downregulation is associated with enhanced cell proliferation, metastatic potential, and reduced apoptosis; here, its ceRNA activity modulates the expression of factors such as PDCD4."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in ovarian cancer, LRRC75A‐AS1 is implicated in the modulation of the immune microenvironment through a ceRNA axis (with hsa‐miR‐330-5p) that results in the upregulation of CDK4/6, contributing to immunosuppression and poorer prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its roles in malignancies, differential expression of LRRC75A‐AS1 in clinical specimens from patients with multiple sclerosis suggests that it may function in the regulation of inflammatory and autoimmune processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, genomic analyses have incorporated LRRC75A‐AS1 into risk‐assessment panels for acute myeloid leukemia and identified its amplification in osteosarcoma, emphasizing its potential prognostic significance and contribution to oncogenesis in hematological and bone malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sijie Li, Di Wu, Hongyao Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02821-2"}], "href": "https://doi.org/10.1038/s41419-020-02821-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32811810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32811810"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lizhang Han, Zhonggang Li, Yuquan Jiang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LRRC75A-AS1 inhibits cell proliferation and migration in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Biol Med (Maywood) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1535370219874339"}], "href": "https://doi.org/10.1177/1535370219874339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31505952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31505952"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Quantang Pang, Yanyan Wang, Dapeng Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2020.1831373"}], "href": "https://doi.org/10.1080/15384047.2020.1831373"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33131397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33131397"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chen Liu, Yuhan Huang, Yaoyuan Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Immunological Role of CDK4/6 and Potential Mechanism Exploration in Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2021.799171"}], "href": "https://doi.org/10.3389/fimmu.2021.799171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35095879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35095879"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M Santoro, V Nociti, M Lucchini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A pilot study of lncRNAs expression profile in serum of progressive multiple sclerosis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202003_20694"}], "href": "https://doi.org/10.26355/eurrev_202003_20694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32271444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32271444"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fangce Wang, Xiaoxue Tian, Jie Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A three‑lncRNA signature for prognosis prediction of acute myeloid leukemia in patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9139"}], "href": "https://doi.org/10.3892/mmr.2018.9139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29901168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29901168"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Joeri Both, Thijs Wu, Anneloor L M A Ten Asbroek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic Properties of Candidate Oncogenes in Chromosome Region 17p11.2p12 in Human Osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytogenet Genome Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000451046"}], "href": "https://doi.org/10.1159/000451046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27846620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27846620"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yan Zhao, Xinxin Liu, Keshuai Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological value of long non-coding RNA profiles in gastrointestinal stromal tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.11946"}], "href": "https://doi.org/10.7717/peerj.11946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34557343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34557343"}]}]}]}