LSAMP Gene

HGNC Family	Immunoglobulin superfamily domain containing
Name	limbic system-associated membrane protein
Description	This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The LSAMP gene encodes a glycosylphosphatidylinositol‐anchored cell adhesion molecule that is predominantly expressed in limbic and related brain regions, where it plays a critical role in regulating neurite outgrowth, synaptic connectivity, and circuit formation. Studies in mice have demonstrated that loss of LSAMP alters neuronal network properties, resulting in heightened reactivity to novel environments, reduced anxiety‐like behavior, impaired spatial learning, and aberrant stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In parallel, LSAMP has emerged as a candidate tumor suppressor in several cancer types. In osteosarcoma, for example, focal deletions and reduced expression of LSAMP have been linked to increased cell proliferation, poorer patient survival, and delayed tumor differentiation, while restoration of LSAMP expression attenuates cell growth and tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " Similarly, a recurrent deletion at the LSAMP locus has been observed in prostate cancer of African American patients, where it is associated with more rapid disease progression, and genetic variants resulting in diminished LSAMP expression appear to promote smooth muscle cell proliferation in the arterial wall, potentially contributing to coronary atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, a long non‐coding RNA transcribed antisense to LSAMP (LOC285194) has been implicated in tumor suppression, underscoring the importance of this locus in regulating cell growth.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elizabeth Haldeman Catania, Aurea Pimenta, Pat Levitt "}, {"type": "b", "children": [{"type": "t", "text": "Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbr.2007.11.022"}], "href": "https://doi.org/10.1016/j.bbr.2007.11.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18199495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18199495"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shenfeng Qiu, Danielle L Champagne, Melinda Peters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2010.02.013"}], "href": "https://doi.org/10.1016/j.biopsych.2010.02.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20385375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20385375"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jürgen Innos, Mari-Anne Philips, Este Leidmaa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbr.2010.09.019"}], "href": "https://doi.org/10.1016/j.bbr.2010.09.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20888367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20888367"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "K Koido, T Traks, R Balõtšev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2012.74"}], "href": "https://doi.org/10.1038/tp.2012.74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22892717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22892717"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stine H Kresse, Hege O Ohnstad, Erik B Paulsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20675"}], "href": "https://doi.org/10.1002/gcc.20675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19441093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19441093"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chueh-Chuan Yen, Wei-Ming Chen, Tain-Hsiung Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo_00000390"}], "href": "https://doi.org/10.3892/ijo_00000390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19724913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19724913"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tale Barøy, Stine H Kresse, Magne Skårn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-93"}], "href": "https://doi.org/10.1186/1476-4598-13-93"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24885297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24885297"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gyorgy Petrovics, Hua Li, Tanja Stümpel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2015.10.028"}], "href": "https://doi.org/10.1016/j.ebiom.2015.10.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26844274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26844274"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "L Wang, E R Hauser, S H Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1469-1809.2008.00433.x"}], "href": "https://doi.org/10.1111/j.1469-1809.2008.00433.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18318786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18318786"}]}]}]}
Synonyms	LAMP, IGLON3
Proteins	LSAMP_HUMAN
NCBI Gene ID	4045
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LSAMP has 6,235 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for LSAMP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LSAMP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by LSAMP gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LSAMP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LSAMP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LSAMP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LSAMP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LSAMP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LSAMP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LSAMP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LSAMP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LSAMP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LSAMP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LSAMP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LSAMP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LSAMP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LSAMP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LSAMP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LSAMP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LSAMP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LSAMP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LSAMP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LSAMP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LSAMP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LSAMP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LSAMP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LSAMP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LSAMP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LSAMP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with LSAMP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LSAMP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LSAMP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LSAMP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LSAMP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LSAMP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LSAMP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LSAMP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LSAMP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LSAMP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LSAMP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with LSAMP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with LSAMP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.