{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the potential significance of the long noncoding RNA LSAMP‐AS1 in cancer biology. In osteosarcoma, a recurrent chromosomal deletion selectively targets the tumor suppressor gene LSAMP, with its loss leading to increased cell proliferation and accelerated tumor growth via deregulation of pathways that include HES1, CTAG2, and KLF10."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although LSAMP‐AS1 was not directly examined in the context of osteosarcoma, its antisense relationship to LSAMP suggests that it might contribute to or regulate this tumor suppressor pathway. In a separate study of cellular senescence, global changes in lncRNA expression were observed with several novel transcripts affecting key senescence phenotypes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", underscoring the diverse regulatory roles of noncoding RNAs in critical cellular processes. Furthermore, an integrated analysis in laryngeal squamous cell carcinoma revealed that LSAMP‐AS1 functions as part of a competitive endogenous RNA network, wherein its altered expression is significantly associated with patient prognosis and may modulate pathways related to extracellular matrix organization, calcium signaling, and metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these observations suggest that LSAMP‐AS1 may represent an important regulatory node in tumorigenesis—potentially influencing LSAMP expression and related oncogenic pathways—and holds promise as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tale Barøy, Stine H Kresse, Magne Skårn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-93"}], "href": "https://doi.org/10.1186/1476-4598-13-93"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24885297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24885297"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kotb Abdelmohsen, Amaresh Panda, Min-Ju Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Senescence-associated lncRNAs: senescence-associated long noncoding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12115"}], "href": "https://doi.org/10.1111/acel.12115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23758631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23758631"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuehui Liu, Fan Ye "}, {"type": "b", "children": [{"type": "t", "text": "Construction and integrated analysis of crosstalking ceRNAs networks in laryngeal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.7380"}], "href": "https://doi.org/10.7717/peerj.7380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31367490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31367490"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xing Hua, Zhen Liu, Min Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retraction notice to \"LSAMP-AS1 binds to microRNA-183-5p to suppress the progression of prostate cancer by up-regulating the tumor suppressor DCN\" [eBioMedicine 50 (2019) 178 - 190]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2021.103665"}], "href": "https://doi.org/10.1016/j.ebiom.2021.103665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34717838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34717838"}]}]}]}