{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"utf-8\">\n <title>LUNAR1 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n LUNAR1 is a long noncoding RNA whose expression is directly induced by Notch signaling and plays a critical oncogenic role in several tumor types. In T‐cell acute lymphoblastic leukemia (T‐ALL), LUNAR1 is transcriptionally activated by the Notch1/RBPJκ complex, thereby enhancing IGF1 receptor (IGF1R) mRNA expression and sustaining IGF1 signaling—a mechanism that is essential for leukemic cell growth both in vitro and in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer (CRC), elevated LUNAR1 levels are associated with more aggressive tumor behavior and poorer overall survival. Functional studies revealed that LUNAR1 promotes cancer cell proliferation, migration, and invasion by acting as a competing endogenous RNA that sponges miR‑495‑3p, thereby modulating the MYCBP axis and reinforcing IGF1 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, inclusion of LUNAR1 in prognostic lncRNA signatures further supports its potential utility as a biomarker for disease outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Additional investigations have also connected LUNAR1 to enhanced angiogenesis and cell survival in other contexts, emphasizing its broader role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thomas Trimarchi, Erhan Bilal, Panagiotis Ntziachristos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.05.049"}], "href": "https://doi.org/10.1016/j.cell.2014.05.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25083870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25083870"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nashwa El-Khazragy, Mahfouz A Abdel Aziz, Manar Hesham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) predicts poor outcome in pediatric T-acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2021.152149"}], "href": "https://doi.org/10.1016/j.imbio.2021.152149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34735923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34735923"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jiajie Qian, Alok Garg, Fuqiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR‑495‑3p/MYCBP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2020.5128"}], "href": "https://doi.org/10.3892/ijo.2020.5128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33300052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33300052"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zixi Zhang, Gai Li, He Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Novel Notch-induced Long Noncoding RNA LUNAR1 Determines the Proliferation and Prognosis of Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-56536-2"}], "href": "https://doi.org/10.1038/s41598-019-56536-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31882986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31882986"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jian Zhao, Jian Xu, An-Quan Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Six-LncRNA Expression Signature Associated with Prognosis of Colorectal Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000494868"}], "href": "https://doi.org/10.1159/000494868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30396175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30396175"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wenbin Lu, Zulong Sheng, Ziwei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-LUNAR1 Levels Are Closely Related to Coronary Collaterals in Patients with Chronic Total Coronary Occlusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cardiovasc Transl Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12265-019-09917-x"}], "href": "https://doi.org/10.1007/s12265-019-09917-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31997261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31997261"}]}]}]}