{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LY6L is a member of the LY6/urokinase‐type plasminogen activator receptor (uPAR) superfamily, a group of cysteine‐rich proteins unified by a distinctive “three‐finger” LU domain formed through a conserved disulfide bond pattern. Studies of LY6 family proteins show that, despite sharing this common tertiary structure, individual members can differ markedly in their subcellular localization and biological functions. For example, many proteins in this family are anchored to the cell membrane via GPI anchors or exist in secreted forms, implicating them in diverse cellular processes ranging from immune cell regulation to signal transduction and cell–cell communication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although detailed characterization of LY6L specifically is still emerging, its genomic context within conserved syntenic regions on human chromosome 8 and the corresponding mouse chromosome indicates a preserved evolutionary role, which is often associated with critical functions in the modulation of immune responses and cellular adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additionally, evidence from experimental disease models, such as hypoxic pulmonary hypertension, has identified differential expression of LY6L—along with related long noncoding RNAs—suggesting that LY6L may engage in post-transcriptional regulation as a competing endogenous RNA (ceRNA) that influences inflammatory and immune signalling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, reports discussing related LY6 family antigens (e.g., the well‐known Stem Cell Antigen-1) support the view that these proteins are integral to cellular differentiation and immune modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Taken together, while the precise mechanisms by which LY6L acts are not yet fully defined, current findings indicate that it likely plays an important role in both structural cell surface interactions and regulatory functions in health and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chelsea L Loughner, Elspeth A Bruford, Monica S McAndrews, et al. 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"}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LY6S,"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunohorizons (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/immunohorizons.2200018"}], "href": "https://doi.org/10.4049/immunohorizons.2200018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35440514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35440514"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jie Liu, Yishu Deng, Zeqin Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and analysis of the abnormal lncRNA-miRNA-mRNA network in hypoxic pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20210021"}], "href": "https://doi.org/10.1042/BSR20210021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34374413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34374413"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Geeta Upadhyay "}, {"type": "b", "children": [{"type": "t", "text": "Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.00819"}], "href": "https://doi.org/10.3389/fimmu.2019.00819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31068932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31068932"}]}]}]}