{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LY86‐AS1 is a long non‐coding RNA whose dysregulated expression appears to be associated with several human disorders. In type 2 diabetes mellitus (T2DM), LY86‐AS1 is consistently down‐regulated in peripheral blood and in circulating cell‐free form, with lower expression levels correlating with higher fasting blood sugar levels. This dysregulation supports its proposed role as a diagnostic biomarker for T2DM and highlights its potential involvement in disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of autoimmunity, genetic variation within LY86‐AS1 (e.g., the rs12192707 allele) has been associated with reduced RNA levels, which may modulate the autoimmune response in diseases such as pemphigus foliaceus, suggesting that LY86‐AS1 could play a regulatory role within immune‐related pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, its expression is also altered in neurodegenerative conditions; for instance, in Alzheimer’s disease, LY86‐AS1 levels negatively correlate with Braak stages, hinting at an involvement in the progression or modulation of neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LY86‐AS1 appears to serve as a multifaceted regulator—its altered expression in metabolic, autoimmune, and neurodegenerative disorders underscores its potential as a diagnostic marker and as a key molecule in the modulation of immune and inflammatory responses.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leyla Saeidi, Hamid Ghaedi, Mirsaber Sadatamini, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genetic variability of immune-related lncRNAs: polymorphisms in LINC-PINT and LY86-AS1 are associated with pemphigus foliaceus susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/exd.14275"}], "href": "https://doi.org/10.1111/exd.14275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33394553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33394553"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mei Cao, Huaqing Li, Jian Zhao, et al. 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