{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LYPLAL1‐AS1 is a long noncoding RNA that modulates multiple aspects of mesenchymal stem cell biology. In human adipose‐derived MSCs, decreased LYPLAL1‐AS1 expression is associated with cellular senescence and aging. Mechanistically, LYPLAL1‐AS1 delays senescence by binding to the MIRLET7B promoter to suppress its transcription, thereby downregulating the pro‐senescence miR‐let-7b; accordingly, its overexpression rejuvenates MSCs while its knockdown accelerates senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, LYPLAL1‐AS1 is dramatically upregulated during adipogenic differentiation, where it enhances this process by regulating the stability of desmoplakin (DSP) and inhibiting the Wnt/β-catenin pathway, with DSP knockdown rescuing the differentiation defect caused by LYPLAL1‐AS1 depletion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, large-scale genomic studies have implicated the LYPLAL1‐AS1-containing locus as a functional enhancer region associated with inguinal hernia susceptibility, particularly in ancestrally diverse populations, highlighting its broader relevance to disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanlei Yang, Suying Liu, Chengmei He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13578-022-00782-x"}], "href": "https://doi.org/10.1186/s13578-022-00782-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35449031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35449031"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanlei Yang, Junfen Fan, Haoying Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LYPLAL1-AS1 regulates adipogenic differentiation of human mesenchymal stem cells by targeting desmoplakin and inhibiting the Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Discov (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41420-021-00500-5"}], "href": "https://doi.org/10.1038/s41420-021-00500-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33993187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33993187"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hélène Choquet, Weiyu Li, Jie Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddac003"}], "href": "https://doi.org/10.1093/hmg/ddac003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35022708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35022708"}]}]}]}