{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A novel noncoding RNA, MACROD2‑AS1, was recently implicated in the genetic architecture of autism spectrum disorders through a gene‐based association analysis using a multi–SNP approach. In this study, a variable threshold method, termed the Optimal P–value Threshold Pedigree Disequilibrium Test, was applied to a family–based autism GWAS dataset and identified MACROD2‑AS1 as significantly associated with disease risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its precise biological function remains to be fully elucidated, the association suggests that MACROD2‑AS1 might play a regulatory role in neurodevelopmental processes. This finding adds to the growing body of evidence that noncoding genomic elements can have significant impacts on complex diseases. In parallel, advances in genomic technologies—such as the use of Hi–C for detecting both balanced and unbalanced chromosomal rearrangements in primary tumors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and array comparative genomic hybridization for mapping copy number changes affecting noncoding RNAs in colorectal cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—underscore the critical importance of comprehensive genomic analyses in uncovering the multifaceted roles of noncoding RNAs in human disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi-Ting Wang, Pei-Yuan Sung, Peng-Lin Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-015-1620-3"}], "href": "https://doi.org/10.1186/s12864-015-1620-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25975968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25975968"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Louise Harewood, Kamal Kishore, Matthew D Eldridge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13059-017-1253-8"}], "href": "https://doi.org/10.1186/s13059-017-1253-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28655341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28655341"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eleanor J Davison, Patrick S Tarpey, Heike Fiegler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20252"}], "href": "https://doi.org/10.1002/gcc.20252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16110499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16110499"}]}]}]}