{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n MAFA‐AS1 is an emerging long noncoding RNA whose dysregulation appears to influence the behavior and clinical outcomes of several diseases. In hepatocellular carcinoma, MAFA‐AS1 has been identified as a prognostic indicator with high expression predicting poor overall and disease‐free survival. Bioinformatics analyses and functional studies suggest that in this context MAFA‐AS1 may promote tumor progression and drug resistance by modulating key regulators – for example, by sponging miR‑3196 to upregulate STRN4 and by interacting with splicing factors SRSF1/SRSF9 while coordinating with miR210."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in lung adenocarcinoma MAFA‐AS1 is incorporated as a component of an eight‐lncRNA prognostic signature that correlates with tumor immune infiltration and survival risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, studies in colon cancer have revealed that MAFA‐AS1 is downregulated, potentially reflecting epigenetic silencing through hypermethylation, suggesting a context‐dependent role that may differ from its oncogenic functions in liver or lung malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, MAFA‐AS1 has been identified as a candidate prognostic biomarker in diffuse large B‐cell lymphoma, and its dysregulation in diabetic cataract further implies involvement in diverse pathological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuting Zhan, Xin-Yuan Guan, Yan Li "}, {"type": "b", "children": [{"type": "t", "text": "MAFA-AS1, a long non-coding RNA, predicts for poor survival of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/tcr.2020.03.11"}], "href": "https://doi.org/10.21037/tcr.2020.03.11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35117604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35117604"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tianming Chen, Bin Huang, Yaozhen Pan "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA MAFG-AS1 Promotes Cell Proliferation, Migration, and EMT by miR-3196/STRN4 in Drug-Resistant Cells of Liver Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.688603"}], "href": "https://doi.org/10.3389/fcell.2021.688603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34386494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34386494"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Chen, Xiuxiu Zhang, Jinze Li, et al. 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