| Name | MAGI1 antisense RNA 1 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided offers an extensive overview of the roles of parvalbumin‐expressing (PV+) GABAergic interneurons in shaping cortical and hippocampal network dynamics. Multiple reports demonstrate that PV+ cells influence sensory processing, spatial working memory, synaptic gain, and overall network synchrony. Such studies have linked the dysfunction of these neurons with various neurologic and psychiatric conditions—including autism, schizophrenia, epilepsy, and neurodegeneration—by examining their intrinsic excitability, calcium‐buffering properties, synaptic integration, and plasticity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite the comprehensive nature of these investigations into interneuron circuitry, synaptic transmission, and calcium‐dependent signaling, not a single abstract addresses or even mentions MAGI1‐AS1. In other words, while these studies advance our understanding of the cellular and network mechanisms mediated by PV+ interneurons, they do not provide any insight into the expression, function, or regulatory role of the long noncoding RNA MAGI1‐AS1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the compiled work richly documents the molecular and network-level functions of PV+ interneurons—including their contributions to precise synaptic inhibition, calcium handling, and network plasticity—it does not address MAGI1‐AS1 in any capacity. Therefore, based on the present set of abstracts, no conclusions regarding the function of MAGI1‐AS1 can be drawn, underscoring the need for future research specifically focused on this long noncoding RNA.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shozo Jinno, Toshio Kosaka "}, {"type": "b", "children": [{"type": "t", "text": "Patterns of expression of calcium binding proteins and neuronal nitric oxide synthase in different populations of hippocampal GABAergic neurons in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comp Neurol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cne.10251"}], "href": "https://doi.org/10.1002/cne.10251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12115690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12115690"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Martin Vreugdenhil, John G R Jefferys, Marco R Celio, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms15039"}], "href": "https://doi.org/10.1038/ncomms15039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28382952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28382952"}]}]}]}
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| NCBI Gene ID | 100873983 |
| API | |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MAGI1-AS1 has 160 functional associations with biological entities spanning 2 categories (cell line, cell type or tissue, gene, protein or microRNA) extracted from 5 datasets.
Click the + buttons to view associations for MAGI1-AS1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAGI1-AS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAGI1-AS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MAGI1-AS1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAGI1-AS1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MAGI1-AS1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |