{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that the long non‐coding RNA MAGI1‐IT1 exerts context‐dependent roles in human diseases. In several cancers, MAGI1‐IT1 is upregulated and functions as an oncogenic factor. For instance, in non‐small cell lung cancer (NSCLC), elevated MAGI1‐IT1 levels are associated with larger tumors, positive metastasis, and advanced disease stage, and it promotes cellular proliferation by sponging miR‑512‑3p to upregulate AKT1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In epithelial ovarian cancer (EOC), MAGI1‐IT1 is overexpressed in metastatic tissues and correlates with advanced FIGO stage; functional studies indicate that its upregulation facilitates epithelial–mesenchymal transition (EMT), thereby enhancing migration, invasion, and intraperitoneal metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in gastric cancer, increased MAGI1‐IT1 expression promotes cell proliferation through modulation of the miR‑302d‑3p/IGF1 axis, and its high expression predicts poorer overall survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast to its oncogenic effects in these tumors, MAGI1‐IT1 appears to act as a negative regulator in cardiac hypertrophy (CH). Network analyses have highlighted its relevance among CH‐associated lncRNAs"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and experimental evidence shows that MAGI1‐IT1 is downregulated in angiotensin II–induced hypertrophic cardiomyocytes. Overexpression of MAGI1‐IT1 in these cells counteracts hypertrophy by sponging miR‑302e, which in turn relieves repression of DKK1 and leads to subsequent inactivation of the Wnt/β‑catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings establish MAGI1‐IT1 as a multifunctional lncRNA that promotes tumor progression in diverse cancers by acting as a competing endogenous RNA, while in the heart it serves a protective role by attenuating pathological hypertrophy. This dual functionality underscores the potential of MAGI1‐IT1 both as a prognostic biomarker and as a therapeutic target in cancer and cardiovascular diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Zhang, H-X Chen, S-N Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGI1-IT1 stimulates proliferation in non-small cell lung cancer by upregulating AKT1 as a ceRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202001_20046"}], "href": "https://doi.org/10.26355/eurrev_202001_20046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32016970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32016970"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hao Gao, Xiaofeng Li, Guangxi Zhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA MAGI1-IT1 promoted invasion and metastasis of epithelial ovarian cancer via the miR-200a/ZEB axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2019.1618121"}], "href": "https://doi.org/10.1080/15384101.2019.1618121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31122127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31122127"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qinge Wang, Min Gu, Yun Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Long Noncoding RNA MAGI1-IT1 Regulates the miR-302d-3p/IGF1 Axis to Control Gastric Cancer Cell Proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S305108"}], "href": "https://doi.org/10.2147/CMAR.S305108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33833579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33833579"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chao Song, Jian Zhang, Yan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction and analysis of cardiac hypertrophy-associated lncRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7312"}], "href": "https://doi.org/10.18632/oncotarget.7312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26872060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26872060"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Qinghua Zhang, Fengshuang Wang, Fenghua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA MAGI1-IT1 regulates cardiac hypertrophy by modulating miR-302e/DKK1/Wnt/beta-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28964"}], "href": "https://doi.org/10.1002/jcp.28964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31222747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31222747"}]}]}]}