{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n This study demonstrates that the long non‐coding RNA MAGI2‐AS3 is significantly downregulated in non‐small cell lung cancer (NSCLC) tissues and cell lines, suggesting a tumor‐suppressive function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional assays—including CCK-8, EdU, colony formation, and Transwell migration/invasion tests—revealed that overexpression of MAGI2‐AS3 markedly inhibits NSCLC cell proliferation, migration, and invasion. Mechanistically, MAGI2‐AS3 exerts its tumor‐suppressive effects by modulating the miR-629-5p/TXNIP axis, thereby dampening pro-oncogenic signaling pathways. In vivo experiments using a nude mice model further confirmed its inhibitory effect on tumor progression. These findings highlight the potential of MAGI2‐AS3 as a promising therapeutic target in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Gong, Lei Ma, Chunlei Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MAGI2-AS3 acts as a tumor suppressor that attenuates non-small cell lung cancer progression by targeting the miR-629-5p/TXNIP axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Transl Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/atm-21-6466"}], "href": "https://doi.org/10.21037/atm-21-6466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35071487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35071487"}]}]}]}