MAJIN Gene

Name membrane anchored junction protein
Description Predicted to enable DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within double-strand break repair involved in meiotic recombination; oogenesis; and spermatogenesis. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary
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This molecular “bridge” is essential for the dynamic “telomere cap exchange” during early meiotic prophase—a process regulated by CDK‐dependent phosphorylation that ensures proper chromosome movement, homolog pairing, and recombination.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, MAJIN directly interacts with components of the nuclear envelope such as SUN1—often in conjunction with factors like SPDYA and CDK2—to reinforce telomere–NE associations and effectively transduce cytoskeletal forces required for rapid telomere movements."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Genetic analyses further highlight its essential role; mutations and rare variants in MAJIN have been implicated in human cases of non‐obstructive azoospermia and infertility, underscoring the protein’s pivotal function in gametogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n The high degree of structural and functional conservation of MAJIN across metazoans further emphasizes its fundamental role in mediating the specialized telomere–nuclear envelope interactions that safeguard genome integrity during meiotic progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroki Shibuya, Abrahan Hernández-Hernández, Akihiro Morimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.10.030"}], "href": "https://doi.org/10.1016/j.cell.2015.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26548954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26548954"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Wang, Yanyan Chen, Juan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-08437-1"}], "href": "https://doi.org/10.1038/s41467-019-08437-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30718482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30718482"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "James M Dunce, Amy E Milburn, Manickam Gurusaran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07794-7"}], "href": "https://doi.org/10.1038/s41467-018-07794-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30559341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30559341"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Irene da Cruz, Céline Brochier-Armanet, Ricardo Benavente "}, {"type": "b", "children": [{"type": "t", "text": "The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Evol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12862-020-01612-9"}], "href": "https://doi.org/10.1186/s12862-020-01612-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32408858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32408858"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guishuan Wang, Xiaolong Wu, Liwei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2020.00845"}], "href": "https://doi.org/10.3389/fcell.2020.00845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015044"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Albert Salas-Huetos, Frank Tüttelmann, Margot J Wyrwoll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-020-02236-1"}], "href": "https://doi.org/10.1007/s00439-020-02236-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33211200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33211200"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Houda Harmak, Hicham Charoute, Salaheddine Redouane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Computational Analysis of the Potential Impact of MTC Complex Missenses SNPs Associated with Male Infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/1664825"}], "href": "https://doi.org/10.1155/2022/1664825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35342767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35342767"}]}]}]}
NCBI Gene ID 283129
API
Download Associations
Predicted Functions View MAJIN's ARCHS4 Predicted Functions.
Co-expressed Genes View MAJIN's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MAJIN's ARCHS4 Predicted Functions.

Functional Associations

MAJIN has 1,046 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.

Click the + buttons to view associations for MAJIN from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MAJIN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with MAJIN gene from the CellMarker Gene-Cell Type Associations dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of MAJIN gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing MAJIN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with MAJIN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with MAJIN gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with MAJIN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
GO Biological Process Annotations 2025 biological processes involving MAJIN gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2025 cellular components containing MAJIN protein from the curated GO Cellular Component Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of MAJIN gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with MAJIN gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of MAJIN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of MAJIN gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of MAJIN gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of MAJIN gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of MAJIN gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of MAJIN protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of MAJIN protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with MAJIN protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.