{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNAs (lncRNAs) have emerged as key regulators of gene transcription under diverse biological conditions. In several high‐throughput studies, MAMDC2‑AS1 has been implicated in modulating host cellular responses in both viral infections and cancers. For instance, during herpes simplex virus type 1 (HSV‑1) infection, altered lncRNA expression—including that of MAMDC2‑AS1—appears to influence host transcriptional programs by affecting pathways involved in chromatin assembly, neuronal development, and innate immune responses (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, by integrating gene interaction networks into survival prediction models, studies have identified MAMDC2‑AS1 as part of prognostic signatures in cancers such as glioblastoma multiforme and esophageal squamous cell carcinoma, suggesting its potential role in tumor progression and patient risk stratification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additional analyses in neuroblastoma have also highlighted MAMDC2‑AS1 among critical lncRNAs that may contribute to tumor pathogenesis, metastasis, and relapse."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Collectively, these findings indicate that MAMDC2‑AS1 is a multifunctional lncRNA involved in the regulation of key host transcriptional networks during viral infection and in the progression of various cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Benxia Hu, Yongxia Huo, Guijun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional prediction of differentially expressed lncRNAs in HSV-1 infected human foreskin fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virol J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12985-016-0592-5"}], "href": "https://doi.org/10.1186/s12985-016-0592-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27496175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27496175"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yiliang Wang, Lianzhou Huang, Yun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-cell RNA-sequencing analysis identifies host long noncoding RNA MAMDC2-AS1 as a co-factor for HSV-1 nuclear transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.42556"}], "href": "https://doi.org/10.7150/ijbs.42556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32226304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32226304"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Wang, Wei Liu "}, {"type": "b", "children": [{"type": "t", "text": "Integration of gene interaction information into a reweighted random survival forest approach for accurate survival prediction and survival biomarker discovery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-31497-0"}], "href": "https://doi.org/10.1038/s41598-018-31497-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30181543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30181543"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bharat Prajapati, Mena Fatma, Mahar Fatima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of lncRNAs Associated With Neuroblastoma in Cross-Sectional Databases: Potential Biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Mol Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fnmol.2019.00293"}], "href": "https://doi.org/10.3389/fnmol.2019.00293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31920530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31920530"}]}]}]}