{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although neither abstract explicitly mentions MAN1B1‑AS1, the studies provide context that may help infer potential roles for this antisense long non‑coding RNA. In the inflammatory bowel disease study, genome‑wide analysis of rare copy number variations identified numerous genomic loci—and highlighted genes involved in immune regulation and intracellular signalling—as being associated with disease risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the diabetic foot ulcer study, profiling of differentially expressed lncRNAs revealed co‑expression networks enriched for functions such as ERK1/2 cascade regulation, centrosome duplication, and DNA repair, which are critical cellular processes in wound healing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Given the widespread regulatory activities of lncRNAs in both immune modulation and tissue repair, it is plausible that MAN1B1‑AS1 may serve as a regulatory element influencing similar pathways. However, its specific function remains to be defined experimentally. Future studies that directly target MAN1B1‑AS1 will be necessary to elucidate its role in these processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Svetlana Frenkel, Charles N Bernstein, Michael Sargent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis identifies rare copy number variations associated with inflammatory bowel disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0217846"}], "href": "https://doi.org/10.1371/journal.pone.0217846"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31185018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31185018"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pijun Yu, Jian Guo, Junjie Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Co-expression network analysis revealing the key lncRNAs in diabetic foot ulcers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5114/aoms.2019.84699"}], "href": "https://doi.org/10.5114/aoms.2019.84699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31572456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31572456"}]}]}]}