{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies indicate that the long noncoding RNA MAP3K14‑AS1 plays a regulatory role in processes common to both gametogenesis and tumorigenesis. Data from investigations of lncRNAs in gametogenic and cancer tissues show that molecules like MAP3K14‑AS1 are involved in key cellular functions—including modulation of gene expression, chromatin dynamics, and telomere biology—that underpin both normal germ cell development and malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, emerging evidence from methylation analyses in circulating cell‑free DNA of colorectal cancer patients suggests that epigenetic modifications involving loci such as MAP3K14‑AS1 can serve as robust biomarkers to monitor tumor burden and therapeutic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Finally, the potential involvement of MAP3K14‑AS1 in major signaling cascades—for example, those governed by Wnt/β‑catenin and PI3K/AKT/mTOR pathways—highlights its promise not only as an indicator for early detection and prognostic assessment but also as a candidate for therapeutic targeting in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ali Dianatpour, Soudeh Ghafouri-Fard "}, {"type": "b", "children": [{"type": "t", "text": "Long Non Coding RNA Expression Intersecting Cancer and Spermatogenesis: A Systematic Review"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.22034/APJCP.2017.18.10.2601"}], "href": "https://doi.org/10.22034/APJCP.2017.18.10.2601"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29072050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29072050"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ludovic Barault, Alessio Amatu, Giulia Siravegna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2016-313372"}], "href": "https://doi.org/10.1136/gutjnl-2016-313372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28982739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28982739"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mifanwy Reece, Hariti Saluja, Paul Hollington, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Use of Circulating Tumor DNA to Monitor and Predict Response to Treatment in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.01118"}], "href": "https://doi.org/10.3389/fgene.2019.01118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31824558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31824558"}]}]}]}