{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLncRNA MAP3K20‐AS1 (also known as MLK7‐AS1) has been identified as significantly upregulated in gastric cancer tissues compared with adjacent normal tissues, where its elevated expression correlates with shorter patient survival and poorer prognosis. Functional studies indicate that silencing MAP3K20‐AS1 impairs cancer cell proliferation and induces apoptosis. Mechanistically, MAP3K20‐AS1 interacts with the DNA methyltransferase Dnmt1 and recruits it to the miR‑375 promoter, resulting in hypermethylation and repression of this tumor‐suppressive microRNA. The consequent downregulation of miR‑375 contributes to enhanced cell growth and tumor progression, positioning MAP3K20‐AS1 as both a potential prognostic marker and a therapeutic target in gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, several other studies have underscored the importance of noncoding RNA–mediated regulation of microRNAs in diverse pathological settings. For instance, investigations in endometriosis have demonstrated that restoration of specific microRNAs (such as miR‑488) can suppress aberrant cellular proliferation and migration by targeting key signaling mediators, thereby mitigating disease progression. Similar regulatory mechanisms of microRNAs have been implicated in processes related to fracture healing, highlighting the broad biological roles of noncoding RNAs in tissue repair and remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional evidence from studies in hepatic fibrosis, podocyte apoptosis, and even intracerebral hemorrhage further emphasizes the pervasive impact of noncoding RNA networks in disease modulation. For example, miR‑488 variants have been shown to influence the activation of hepatic stellate cells and podocyte survival via their downstream targets, while dysregulation of other noncoding RNAs (like circAFF2) contributes to the pathogenesis of intracerebral hemorrhage. Collectively, these findings indicate that although the mechanistic details may differ across disease contexts, noncoding RNAs—including MAP3K20‐AS1 in gastric cancer—play critical roles in fine‐tuning gene expression and cellular signaling, ultimately affecting disease outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yongsheng Quan, Yan Zhang, Wei Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of long non-coding RNA MAP3K20 antisense RNA 1 inhibits gastric cancer growth through epigenetically regulating miR-375."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.02.072"}], "href": "https://doi.org/10.1016/j.bbrc.2018.02.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29428732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29428732"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hui Zhu, Xi-Xia Cao, Juan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-488 inhibits endometrial glandular epithelial cell proliferation, migration, and invasion in endometriosis mice via Wnt by inhibiting FZD7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14078"}], "href": "https://doi.org/10.1111/jcmm.14078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30729701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30729701"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "F Wang, X-Y Hu, C Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-488 promotes fracture healing by targeting DKK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201812_16667"}], "href": "https://doi.org/10.26355/eurrev_201812_16667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30575941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30575941"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiannan Qiu, Shasha Wu, Peng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-488-5p mitigates hepatic stellate cell activation and hepatic fibrosis via suppressing TET3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatol Int (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12072-022-10404-w"}], "href": "https://doi.org/10.1007/s12072-022-10404-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36001230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36001230"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuzhen Jie, Ning Ding, Lin Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Homocysteine induces glomerular podocyte apoptosis via up-regulation of miR-488-3p expression in MPC-5 mice]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2022)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36082710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36082710"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Juxing Qi, Chengjie Meng, Jianbing Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircAFF2 Promotes Neuronal Cell Injury in Intracerebral Hemorrhage by Regulating the miR-488/CLSTN3 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2023.10.014"}], "href": "https://doi.org/10.1016/j.neuroscience.2023.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37884088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37884088"}]}]}]}