MAPK7 Gene

HGNC Family	Mitogen-activated protein kinase cascade
Name	mitogen-activated protein kinase 7
Description	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMAPK7, also known as ERK5 or BMK1, is a unique member of the mitogen‐activated protein kinase family distinguished by its extended C‐terminal regulatory tail. This atypical structure mediates auto-inhibition and governs its subcellular localization and transcriptional capability, thereby enabling MAPK7 to directly phosphorylate transcription factors (e.g. c‐Fos) and modulate gene expression. These intrinsic regulatory features underpin its broad roles in cellular signaling and ensure that MAPK7 integrates mitogenic and stress signals in numerous cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer cells, MAPK7 plays a critical role in promoting cell proliferation and survival. For instance, in multiple myeloma, IL-6–dependent activation of MAPK7 drives tumor cell growth and confers resistance to apoptosis, while in breast cancer, its enhanced activity is associated with increased proliferation and has been proposed as a prognostic marker. Moreover, MAPK7 can subvert tumor suppressor functions—evidenced by its interaction with PML—as well as participate in an IL-17–driven cascade that triggers keratinocyte proliferation and tumor formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic roles, MAPK7 is pivotal in maintaining vascular integrity and facilitating tissue repair. In endothelial cells, activation of the MAPK7 cascade fosters a protective phenotype by inducing vasoprotective and anti-thrombotic gene programs—partly through upregulation of transcription factors like KLF4. In parallel, in keratinocytes, MAPK7 signaling supports reepithelialization by modulating cytoskeletal organization and cell migration during wound healing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marcus Buschbeck, Axel Ullrich "}, {"type": "b", "children": [{"type": "t", "text": "The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M412599200"}], "href": "https://doi.org/10.1074/jbc.M412599200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15548525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15548525"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Robert A Winn, Michelle Van Scoyk, Mandy Hammond, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604145200"}], "href": "https://doi.org/10.1074/jbc.M604145200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16835228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16835228"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takanori Sasaki, Hirotada Kojima, Rikiya Kishimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.08.005"}], "href": "https://doi.org/10.1016/j.molcel.2006.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17018293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17018293"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xonia Carvajal-Vergara, Soraya Tabera, Juan C Montero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multifunctional role of Erk5 in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-08-2985"}], "href": "https://doi.org/10.1182/blood-2004-08-2985"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15692064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15692064"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Juan Carlos Montero, Alberto Ocaña, Mar Abad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0005565"}], "href": "https://doi.org/10.1371/journal.pone.0005565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19440538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19440538"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qingkai Yang, Xianming Deng, Bingwen Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.08.008"}], "href": "https://doi.org/10.1016/j.ccr.2010.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20832753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20832753"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ling Wu, Xing Chen, Junjie Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20150204"}], "href": "https://doi.org/10.1084/jem.20150204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26347473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26347473"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Valerie Arnoux, Mayssaa Nassour, Annie L'Helgoualc'h, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erk5 controls Slug expression and keratinocyte activation during wound healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-10-1078"}], "href": "https://doi.org/10.1091/mbc.e07-10-1078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18716062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18716062"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nils Ohnesorge, Dorothee Viemann, Nicole Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.103127"}], "href": "https://doi.org/10.1074/jbc.M110.103127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20551324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20551324"}]}]}]}
Synonyms	PRKM7, BMK1, ERK5
Proteins	MK07_HUMAN
NCBI Gene ID	5598
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAPK7 has 8,789 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 132 datasets.

Click the + buttons to view associations for MAPK7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAPK7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAPK7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAPK7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAPK7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MAPK7 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAPK7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAPK7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MAPK7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAPK7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MAPK7 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAPK7 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAPK7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAPK7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAPK7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAPK7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAPK7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MAPK7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAPK7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAPK7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAPK7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAPK7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAPK7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAPK7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAPK7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAPK7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate MAPK7 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAPK7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAPK7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAPK7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAPK7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAPK7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAPK7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAPK7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MAPK7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.