{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMATN1-AS1 is a long non-coding RNA with oncogenic properties that plays crucial roles in cancer progression. In osteosarcoma, MATN1-AS1 is significantly overexpressed in tumor tissues and cell lines, and its elevated levels correlate with advanced Enneking staging, lung metastasis, and distinct histologic subtypes. Functionally, knockdown of MATN1-AS1 impairs cell proliferation, migration, and invasion by sponging miR-1299, while high levels of this lncRNA predict shorter overall and recurrence-free survival, thereby underscoring its potential as both a prognostic marker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nSimilarly, in cervical cancer, MATN1-AS1 is markedly upregulated in cancer tissues as well as in patient serum, compared to adjacent normal tissues and benign lesions. Its expression is positively correlated with that of miR-200b, and increased levels are associated with poor differentiation, larger tumor sizes (≥4 cm), advanced FIGO stages (III–IV), and lymph node metastasis, which in turn reflect a lower 3-year survival rate. Silencing MATN1-AS1 in cervical cancer cell lines leads to a reduction in miR-200b expression, suggesting that MATN1-AS1 functions as a competing endogenous RNA (ceRNA) modulating miR-200b and contributing to cervical cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yongxiang Liu, Dawei Wang, Qinghui Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MATN1-AS1 for Prediction of Prognosis in Osteosarcoma Patients and Its Cellular Function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-021-00394-9"}], "href": "https://doi.org/10.1007/s12033-021-00394-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34542816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34542816"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lijie He, Pu Li, Heping Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of MATN1-AS1 as ceRNA of Mir-200b in tissues and serum of patients with cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-42023-2"}], "href": "https://doi.org/10.1038/s41598-023-42023-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37714866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37714866"}]}]}]}