MCM2 Gene

Name	minichromosome maintenance complex component 2
Description	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMinichromosome maintenance protein 2 (MCM2) is a core component of the hexameric MCM2–7 complex that functions as the replicative DNA helicase essential for both the initiation and elongation phases of eukaryotic DNA replication. Its activity is finely regulated by cell cycle– and damage–responsive kinases—such as ATR, ATM, Cdc7, and cyclin‐dependent kinases—which phosphorylate MCM2 at specific residues in response to DNA damage or during S-phase entry, thereby coupling checkpoint signaling with replication fork progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its helicase role, MCM2 also contributes to the faithful transmission of chromatin structure during DNA replication by acting as a histone chaperone. Structural studies have revealed that its amino‐terminal domain directly binds histone H3–H4 complexes—thereby assisting in the disassembly and reassembly of nucleosomes during replication fork passage—ensuring the recycling of both old and new histones to maintain epigenomic integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNumerous clinical studies have exploited the deregulated expression and phosphorylation status of MCM2 as a sensitive biomarker for cellular proliferation and malignancy. Aberrant MCM2 expression has been correlated with aggressive growth and poor prognostic factors in a variety of cancers—including those of the colon, lung, ovary, breast, head and neck, and even brain tumors—while microRNAs and long noncoding RNAs (e.g., miR‑31 and lnc‑FTX) have been shown to modulate tumorigenesis by directly targeting MCM2 to inhibit DNA replication."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, MCM2 is integrated into wider regulatory networks that coordinate DNA replication with other nuclear processes. It interacts with proteins such as AKAP95 to facilitate the formation of active replication complexes and is a substrate for dephosphorylation by tumor suppressors like PTEN, which in turn help restrain replication fork progression under stress. In addition, emerging evidence indicates that MCM2 may also contribute to RNA polymerase II–dependent transcription elongation, highlighting its multifunctional nature in nuclear DNA metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies underscore the multifaceted roles of MCM2 not only as an essential motor of the DNA replication machinery but also as a histone chaperone and regulatory hub linking replication, repair, and transcription. Disruptions in its regulation are associated with genomic instability and tumorigenesis, while its expression level serves as a valuable diagnostic and prognostic marker in clinical oncology. Interventions that modulate MCM2 function—such as viral proteins that interfere with its chromatin loading—further illuminate its central position in maintaining cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David Cortez, Gloria Glick, Stephen J Elledge "}, {"type": "b", "children": [{"type": "t", "text": "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0403410101"}], "href": "https://doi.org/10.1073/pnas.0403410101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15210935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15210935"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alessia Montagnoli, Barbara Valsasina, Deborah Brotherton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512921200"}], "href": "https://doi.org/10.1074/jbc.M512921200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16446360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16446360"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Won-Ho Cho, Young-Joo Lee, Soo-Im Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0604990103"}], "href": "https://doi.org/10.1073/pnas.0604990103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16864800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16864800"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Toshiya Tsuji, Scott B Ficarro, Wei Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e06-03-0241"}], "href": "https://doi.org/10.1091/mbc.e06-03-0241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16899510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16899510"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Y Ishimi, Y Komamura-Kohno, K Arai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical activities associated with mouse Mcm2 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M106861200"}], "href": "https://doi.org/10.1074/jbc.M106861200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11568184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11568184"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nicolas Richet, Danni Liu, Pierre Legrand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv021"}], "href": "https://doi.org/10.1093/nar/gkv021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25618846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25618846"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hongda Huang, Caroline B Strømme, Giulia Saredi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3055"}], "href": "https://doi.org/10.1038/nsmb.3055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26167883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26167883"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "D F Tan, J A Huberman, A Hyland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM2--a promising marker for premalignant lesions of the lung: a cohort study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-1-6"}], "href": "https://doi.org/10.1186/1471-2407-1-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11472637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11472637"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "P Chatrath, I S Scott, L S Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression of minichromosome maintenance protein-2 and Ki67 in laryngeal squamous epithelial lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6601234"}], "href": "https://doi.org/10.1038/sj.bjc.6601234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12966424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12966424"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhiling Yu, Daorong Feng, Chun Liang "}, {"type": "b", "children": [{"type": "t", "text": "Pairwise interactions of the six human MCM protein subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2004.05.024"}], "href": "https://doi.org/10.1016/j.jmb.2004.05.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15236977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15236977"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jun Yang, Nithya Ramnath, Kirsten B Moysich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-6-203"}], "href": "https://doi.org/10.1186/1471-2407-6-203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16882345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16882345"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "H Gakiopoulou, P Korkolopoulou, G Levidou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6603992"}], "href": "https://doi.org/10.1038/sj.bjc.6603992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17940502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17940502"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Constantinos Giaginis, Maria Georgiadou, Konstantina Dimakopoulou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-008-0305-z"}], "href": "https://doi.org/10.1007/s10620-008-0305-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18465232"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18465232"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bozena Werynska, Bartosz Pula, Beata Muszczynska-Bernhard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation between expression of metallothionein and expression of Ki-67 and MCM-2 proliferation markers in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21868526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21868526"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xu Zhang, Yang Teng, Fang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.3822"}], "href": "https://doi.org/10.3892/or.2015.3822"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25738322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25738322"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "F Liu, J-H Yuan, J-F Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.80"}], "href": "https://doi.org/10.1038/onc.2016.80"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27065331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27065331"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Turid Eide, Kristin A Taskén, Cathrine Carlson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300765200"}], "href": "https://doi.org/10.1074/jbc.M300765200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12740381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12740381"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Marylynn Snyder, Xin-Yun Huang, J Jillian Zhang "}, {"type": "b", "children": [{"type": "t", "text": "The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M809471200"}], "href": "https://doi.org/10.1074/jbc.M809471200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19318354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19318354"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jiawen Feng, Jing Liang, Jiaju Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2015.10.016"}], "href": "https://doi.org/10.1016/j.celrep.2015.10.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26549452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26549452"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zhikang Qian, Van Leung-Pineda, Baoqin Xuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1000814"}], "href": "https://doi.org/10.1371/journal.ppat.1000814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20333247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20333247"}]}]}]}
Synonyms	D3S3194, CDC19, DFNA70, BM28, MITOTIN, CDCL1, CCNL1
Proteins	MCM2_HUMAN
NCBI Gene ID	4171
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MCM2 has 12,097 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for MCM2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MCM2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MCM2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCM2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCM2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MCM2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MCM2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCM2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MCM2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MCM2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCM2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCM2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MCM2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MCM2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MCM2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MCM2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCM2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MCM2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MCM2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MCM2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MCM2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MCM2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MCM2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MCM2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	CORUM Protein Complexes	protein complexs containing MCM2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MCM2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MCM2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MCM2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MCM2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MCM2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MCM2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MCM2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MCM2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MCM2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MCM2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCM2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MCM2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MCM2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MCM2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MCM2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MCM2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MCM2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.