{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMCM3AP‐AS1 is a long non‐coding RNA that has emerged as a critical regulator in cancer biology. Numerous studies have demonstrated its oncogenic functions by acting as a competitive endogenous RNA (ceRNA) to modulate key molecular pathways. For example, in glioblastoma, hepatocellular carcinoma, papillary thyroid cancer, and pancreatic cancer, MCM3AP‐AS1 has been implicated in promoting cell proliferation, migration, invasion, and metastasis by sponging specific microRNAs and thereby upregulating oncogenic targets. In breast cancer, it drives malignant progression through the miR‐28‐5p/CENPF axis and is clinically correlated with disease aggressiveness, while in oral squamous cell carcinoma, MCM3AP‐AS1 sequesters miR‐204–5p to enhance FOXC1 expression. Its oncogenic roles have also been explored in colorectal, prostate, endometrioid, and lung cancers (acting via regulators such as miR‐195–5p/E2F3 and via downregulation of tumor‐suppressive RNAs like MEG3), and comprehensive reviews further consolidate its contributions to tumorigenesis, angiogenesis (including via extracellular vesicle‐mediated transfer in cervical cancer), and its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in malignancy, MCM3AP‐AS1 is also involved in non‐cancerous pathologies. In osteoarthritis, altered expression of MCM3AP‐AS1 contributes to the regulation of chondrocyte viability, migration, and inflammatory responses – in part through its interactions with microRNAs such as miR‐142–3p and miR‐138–5p, which in turn modulate targets like SIRT1. Similarly, during osteogenic differentiation of dental pulp stem cells, MCM3AP‐AS1 facilitates the upregulation of key osteogenic markers through a miR‐143–3p/IGFBP5 axis. Moreover, in atherosclerosis, reduced levels of this lncRNA have been linked to enhanced proliferation of aortic smooth muscle cells via sponging of miR‐448 and subsequent regulation of MEF2‐C."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuze Cao, Peng Wang, Shangwei Ning, et al. 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