{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMinichromosome maintenance protein 6 (MCM6) is a highly conserved subunit of the MCM2‐7 complex that acts as the replicative helicase, playing an essential role in both the initiation and elongation phases of DNA replication. Structural and biochemical studies have defined a critical C-terminal “winged helix” domain of MCM6 that directly interacts with Cdt1, thereby facilitating the loading of the helicase complex onto chromatin during replication licensing ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. Moreover, under conditions of cellular stress such as hypoxia, disruption of MCM6 expression contributes to replication arrest and genomic instability, while its regulated function is important for maintaining proper replication fork dynamics ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nElevated MCM6 expression has been widely documented in a variety of human malignancies and is closely associated with increased cellular proliferation, aggressive tumor behavior, and poor clinical outcome. In diverse cancers—including glioma ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "], breast ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "], endometrioid adenocarcinoma ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "], hepatocellular carcinoma ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "], non‐small cell lung carcinoma ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "], intrahepatic cholangiocarcinoma ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "] and clear‐cell renal cell carcinoma ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "]—MCM6 serves as a robust diagnostic and prognostic biomarker. Its overexpression correlates with markers of cell cycle progression and is predictive of tumor recurrence as observed in craniopharyngiomas ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "]. Functional investigations have further demonstrated that MCM6 modulates key signaling pathways—such as PI3K/Akt and E2F1—that govern cell proliferation, epithelial‐to‐mesenchymal transition, and responses to DNA damage; in some tumor models, interactions with other regulatory proteins (e.g., GTSE1 and E6AP) and even incorporation into exosome‐mediated signaling cascades contribute to malignant progression ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "].\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its canonical role in DNA replication, the MCM6 gene locus harbors intronic enhancer elements that modulate the expression of the lactase gene. Single nucleotide polymorphisms within this enhancer are strongly associated with lactase persistence, as evidenced by studies performed in populations ranging from Saudi Arabia ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "] and Britain ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "] to Somali camel‐herders ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "]. Such MCM6‐linked variants have not only been used as genetic proxies for evaluating dairy intake and related health outcomes ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "25"}]}, {"type": "t", "text": "] but emerging evidence also suggests that mutations and alterations in MCM6 structure may compromise its function and contribute to developmental and neurobehavioral disorders ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "29"}]}, {"type": "t", "text": "]. \n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhun Wei, Changdong Liu, Xing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C109.094599"}], "href": "https://doi.org/10.1074/jbc.C109.094599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20202939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20202939"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jingjing Zhang, Lan Yu, Xing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.9.24.14136"}], "href": "https://doi.org/10.4161/cc.9.24.14136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21099365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21099365"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Isabel M Pires, Zuzana Bencokova, Manuela Milani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-2715"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-2715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20103649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20103649"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Vivek M Shastri, Veena Subramanian, Kristina H Schmidt "}, {"type": "b", "children": [{"type": "t", "text": "A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkab663"}], "href": "https://doi.org/10.1093/nar/gkab663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34370039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34370039"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hong-Qing Cai, Zhi-Jian Cheng, Hai-Peng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of MCM6 predicts poor survival in patients with glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2018.04.024"}], "href": "https://doi.org/10.1016/j.humpath.2018.04.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29753008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29753008"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Marianne Samir Makboul Issac, Einas Yousef, Muhammad Ramzan Tahir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2019.07.011"}], "href": "https://doi.org/10.1016/j.neo.2019.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31476594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31476594"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Judicaël Hotton, Mikaël Agopiantz, Agnès Leroux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virchows Arch (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00428-017-2278-9"}], "href": "https://doi.org/10.1007/s00428-017-2278-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29243125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29243125"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wenxian Jia, Li Xie, Xiao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The impact of MCM6 on hepatocellular carcinoma in a Southern Chinese Zhuang population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2020.110171"}], "href": "https://doi.org/10.1016/j.biopha.2020.110171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32403044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32403044"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Charlène Vigouroux, Jean-Matthieu Casse, Shyue-Fang Battaglia-Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2015.05.008"}], "href": "https://doi.org/10.1016/j.lungcan.2015.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26013954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26013954"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chongqing Gao, Jing Li, Fuling Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgad023"}], "href": "https://doi.org/10.1093/carcin/bgad023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37185675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37185675"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nu-Ri Jang, Jina Baek, Younghwii Ko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vivo (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/invivo.12259"}], "href": "https://doi.org/10.21873/invivo.12259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33402477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33402477"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jian-guo Xu, Chao You, Xiao-jie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sichuan Da Xue Xue Bao Yi Xue Ban (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17294730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17294730"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jianguo Xu, Sizhong Zhang, Chao You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-006-9284-0"}], "href": "https://doi.org/10.1007/s11060-006-9284-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17410335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17410335"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A Hendricks, F Gieseler, S Nazzal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-019-5631-3"}], "href": "https://doi.org/10.1186/s12885-019-5631-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31072339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31072339"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yifei Wang, Huarong Chen, Weixin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.75431"}], "href": "https://doi.org/10.7150/thno.75431"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36185598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36185598"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wei Hou, Lu Xu, Tao Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia Induces Tumor-Derived Exosome SNHG16 to Mediate Nasopharyngeal Carcinoma Progression through the miR-23b-5p/MCM6 Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Biochem Biotechnol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12010-023-04558-y"}], "href": "https://doi.org/10.1007/s12010-023-04558-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37119503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37119503"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yanyan Luo, Yun Yang, Cong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.13675"}], "href": "https://doi.org/10.1002/2211-5463.13675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37454373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37454373"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yongchang Zheng, Yue Shi, Si Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Cell Pathol (Amst) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/1038069"}], "href": "https://doi.org/10.1155/2019/1038069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32082966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32082966"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "F Imtiaz, E Savilahti, A Sarnesto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2007.051631"}], "href": "https://doi.org/10.1136/jmg.2007.051631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17911653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17911653"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "George Davey Smith, Debbie A Lawlor, Nic J Timpson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lactase persistence-related genetic variant: population substructure and health outcomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2008.156"}], "href": "https://doi.org/10.1038/ejhg.2008.156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18797476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18797476"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Catherine J E Ingram, Tamiru Oljira Raga, Ayele Tarekegn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Evol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00239-009-9301-y"}], "href": "https://doi.org/10.1007/s00239-009-9301-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19937006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19937006"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nicholas J Timpson, Paul Brennan, Valérie Gaborieau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-09-1019"}], "href": "https://doi.org/10.1158/1055-9965.EPI-09-1019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20447925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20447925"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "R Magiera, C C Schürer-Maly, A Mortsiefer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Are there differences between patients with and without the homozygous--13910CC genetic variant in the MCM-6 gene upstream from the lactase gene?--A non-randomised, two armed intervention study without control group."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/clin.lab.2014.140219"}], "href": "https://doi.org/10.7754/clin.lab.2014.140219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25651706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25651706"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Q Yang, S L Lin, S L Au Yeung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetically predicted milk consumption and bone health, ischemic heart disease and type 2 diabetes: a Mendelian randomization study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Clin Nutr (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejcn.2017.8"}], "href": "https://doi.org/10.1038/ejcn.2017.8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28225053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28225053"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ann E Almazar, Joseph Y Chang, Joseph J Larson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of Lactase Variant MCM6 -13910 C>T Testing and Self-report of Dairy Sensitivity in Patients With Irritable Bowel Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Gastroenterol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MCG.0000000000001065"}], "href": "https://doi.org/10.1097/MCG.0000000000001065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29912753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29912753"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Daphne J Smits, Rachel Schot, Cristiana A Popescu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo MCM6 variants in neurodevelopmental disorders: a recognizable phenotype related to zinc binding residues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-023-02569-7"}], "href": "https://doi.org/10.1007/s00439-023-02569-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37198333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37198333"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yaling Jiang, Yuan Xue, Xinhua Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM6 Inhibits Decidualization via Cross-Talking with ERK Pathway in Human Endometrial Stromal Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-024-01463-5"}], "href": "https://doi.org/10.1007/s43032-024-01463-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38347378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38347378"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "H Zhang, Y-D Lin, M-X Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High MCM6 expression promotes proliferation and correlates with poor prognosis in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202404_35921"}], "href": "https://doi.org/10.26355/eurrev_202404_35921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38639528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38639528"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Md Mostafa Kamal, Md Sohel Mia, Md Omar Faruque, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-62299-2"}], "href": "https://doi.org/10.1038/s41598-024-62299-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38773180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38773180"}]}]}]}