{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMCT-1 is an established oncogene originally discovered through its amplification on chromosome Xq22–24 in T‐cell lymphoma, and its overexpression has been associated with a subset of diffuse large B‐cell lymphomas. Its aberrant activation appears to play an important role in oncogenesis, with increased gene dosage observed in multiple human malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to MCT-1, researchers have identified a processed pseudogene—referred to as PsiMCT-1—located on chromosome 20q11.2, a chromosomal region prone to amplification in breast and ovarian cancers. Although PsiMCT-1 does not encode a functional protein, its existence necessitates careful interpretation of genomic amplification and expression assays, providing insight into the evolutionary dynamics of cancer-associated gene families."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Suvobroto Nandi, Bo Shi, Jonathan Perreault, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the MCT-1 pseudogene: identification and implication of its location in a highly amplified region of chromosome 20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2006.05.003"}], "href": "https://doi.org/10.1016/j.bbaexp.2006.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16815567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16815567"}]}]}]}