MED25 Gene

Name	mediator complex subunit 25
Description	This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMED25 is a specialized subunit of the Mediator complex that plays a central role in relaying transcription‐activating signals. Structural studies using NMR and computational modeling have revealed that its activator interaction domain (ACID) adopts a unique seven‐stranded β‑barrel flanked by α‑helices, creating a hydrophobic cleft that serves as a docking site for diverse transcriptional activators. Notably, this surface interacts with viral transactivators such as VP16 and with cellular factors including members of the ETS family, with mutational and biophysical analyses demonstrating that distinct aromatic motifs within these activators engage different surfaces on MED25. These dynamic, “fuzzy” interactions provide the structural basis for MED25’s ability to integrate multiple input signals into the transcription machinery."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn developmental and metabolic contexts, MED25 acts as an essential transcriptional coactivator. During chondrogenesis, it bridges interactions between Sox9 and the ubiquitin ligase Wwp2 to promote cartilage‐specific gene expression. In hepatic and pancreatic cells, MED25 is recruited by nuclear receptors—including the retinoic acid receptor, HNF4α, and estrogen receptor α—to fine‐tune the expression of genes involved in drug metabolism (e.g., CYP2C9) and lipid homeostasis. Moreover, genetic studies have linked mutations in MED25 to peripheral neuropathies such as Charcot–Marie–Tooth disease and syndromic intellectual disability, highlighting its importance in human development and neuronal function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMED25 is also a prime target for viral strategies and other regulatory networks. Viral proteins—including herpes simplex virus VP16 and the latency‐associated nuclear antigen of Kaposi’s sarcoma–associated herpesvirus—directly engage MED25 to commandeer the host transcriptional machinery and stimulate viral gene expression. In addition, transcription factors such as ATF6α utilize MED25 to recruit Mediator during stress responses, thereby broadening the spectrum of signals converging on RNA polymerase II."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fajun Yang, Rosalie DeBeaumont, Sharleen Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0308676100"}], "href": "https://doi.org/10.1073/pnas.0308676100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14983011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14983011"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "François Bontems, Alexis Verger, Frédérique Dewitte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NMR structure of the human Mediator MED25 ACID domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsb.2010.10.011"}], "href": "https://doi.org/10.1016/j.jsb.2010.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20974256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20974256"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alexander G Milbradt, Madhura Kulkarni, Tingfang Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the VP16 transactivator target in the Mediator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1999"}], "href": "https://doi.org/10.1038/nsmb.1999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21378963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21378963"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Erika Vojnic, André Mourão, Martin Seizl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and VP16 binding of the Mediator Med25 activator interaction domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1997"}], "href": "https://doi.org/10.1038/nsmb.1997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21378965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21378965"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alexander Eletsky, William T Ruyechan, Rong Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution NMR structure of MED25(391-543) comprising the activator-interacting domain (ACID) of human mediator subunit 25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Funct Genomics (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10969-011-9115-1"}], "href": "https://doi.org/10.1007/s10969-011-9115-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21785987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21785987"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Isabelle Landrieu, Alexis Verger, Jean-Luc Baert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv650"}], "href": "https://doi.org/10.1093/nar/gkv650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26130716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26130716"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Simon L Currie, Jedediah J Doane, Kathryn S Evans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2017.06.024"}], "href": "https://doi.org/10.1016/j.jmb.2017.06.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28728983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28728983"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Heather M Jeffery, Robert O J Weinzierl "}, {"type": "b", "children": [{"type": "t", "text": "Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom10091205"}], "href": "https://doi.org/10.3390/biom10091205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32825095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32825095"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hye-Kyung Lee, Ui-Hyun Park, Eun-Joo Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601797"}], "href": "https://doi.org/10.1038/sj.emboj.7601797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17641689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17641689"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Alejandro Leal, Kathrin Huehne, Finn Bauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-009-0183-3"}], "href": "https://doi.org/10.1007/s10048-009-0183-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19290556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19290556"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ritu Rana, Sailesh Surapureddi, Waynekid Kam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00847-10"}], "href": "https://doi.org/10.1128/MCB.00847-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21135126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21135126"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yukio Nakamura, Koji Yamamoto, Xinjun He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1242"}], "href": "https://doi.org/10.1038/ncomms1242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21427722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21427722"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Eun Hee Han, Geun Bae Rha, Young-In Chi "}, {"type": "b", "children": [{"type": "t", "text": "MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0044007"}], "href": "https://doi.org/10.1371/journal.pone.0044007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22952853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22952853"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhe Shi, Wenjun Yang, Joyce A Goldstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Med25 is required for estrogen receptor alpha (ERα)-mediated regulation of human CYP2C9 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2014.06.016"}], "href": "https://doi.org/10.1016/j.bcp.2014.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24960263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24960263"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lina Basel-Vanagaite, Pola Smirin-Yosef, Jenna Lee Essakow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homozygous MED25 mutation implicated in eye-intellectual disability syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-015-1541-x"}], "href": "https://doi.org/10.1007/s00439-015-1541-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25792360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25792360"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jia-Yi Xu, Liang Wu, Zhe Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.22297"}], "href": "https://doi.org/10.1002/tox.22297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27273787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27273787"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ilenia Maini, Edoardo Errichiello, Stefano Giuseppe Caraffi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Improving the phenotype description of Basel-Vanagaite-Smirin-Yosef syndrome, MED25-related: polymicrogyria as a distinctive neuroradiological finding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-020-00625-2"}], "href": "https://doi.org/10.1007/s10048-020-00625-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32816121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32816121"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Maria Roupelieva, Samantha J Griffiths, Elisabeth Kremmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaposi's sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Virol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/vir.0.017715-0"}], "href": "https://doi.org/10.1099/vir.0.017715-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20089804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20089804"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dotan Sela, Juliana J Conkright, Lu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.496968"}], "href": "https://doi.org/10.1074/jbc.M113.496968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23864652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23864652"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Tessa Van Royen, Koen Sedeyn, George D Moschonas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.01297-22"}], "href": "https://doi.org/10.1128/jvi.01297-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36102648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36102648"}]}]}]}
Synonyms	ARC92, PTOV2, BVSYS, TCBAP0758, CMT2B2, ACID1
Proteins	MED25_HUMAN
NCBI Gene ID	81857
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MED25 has 5,816 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for MED25 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MED25 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MED25 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MED25 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MED25 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MED25 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MED25 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MED25 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MED25 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MED25 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MED25 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MED25 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MED25 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MED25 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MED25 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MED25 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MED25 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MED25 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MED25 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MED25 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MED25 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MED25 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MED25 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MED25 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MED25 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MED25 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MED25 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MED25 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MED25 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MED25 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MED25 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MED25 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MED25 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MED25 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MED25 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MED25 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MED25 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MED25 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MED25 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MED25 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MED25 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MED25 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.