{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that MEF2C‐AS1 plays a critical tumor‐suppressive role in cervical cancer by modulating the miR-20b-5p–MEF2C axis. Specifically, both MEF2C-AS1 and its adjacent gene MEF2C are downregulated in cervical cancer tissues and cell lines, correlating with enhanced malignant behaviors. Functional assays revealed that elevating MEF2C-AS1 expression in cervical cancer cells represses proliferation, migration, and angiogenesis by predominantly sequestering miR-20b-5p in the cytoplasm. This “sponging” effect alleviates miRNA-mediated suppression of MEF2C, thereby leading to its upregulation—a mechanism confirmed through gain-of-function and rescue experiments. These findings not only underscore the importance of the MEF2C-AS1–miR-20b-5p–MEF2C regulatory axis in cervical cancer pathogenesis but also suggest that targeting this pathway may offer promising therapeutic avenues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qi Guo, Lijia Zhang, Lei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEF2C-AS1 regulates its nearby gene MEF2C to mediate cervical cancer cell malignant phenotypes in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.09.091"}], "href": "https://doi.org/10.1016/j.bbrc.2022.09.091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36198203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36198203"}]}]}]}