{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe long non‐coding RNA MELTF‑AS1—also referred to as MFI2‑AS1 in several studies—has emerged as a critical regulator in a variety of pathological conditions. In osteoarthritis, elevated MELTF‑AS1 levels promote disease progression by interacting with microRNA‑130a‑3p and the transcription factor TCF4, suggesting a role in modulating inflammatory and degenerative processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, overexpression of MELTF‑AS1 correlates with poor prognosis and advanced stages, acting as a competing endogenous RNA that sponges miR‑134 to upregulate FOXM1, thereby stimulating cell proliferation and metastasis. Similarly, in osteosarcoma, high levels of MELTF‑AS1 promote cell proliferation and migration while suppressing apoptosis through the positive regulation of FOXP4 expression. Moreover, in clear‑cell renal cell carcinoma, increased MELTF‑AS1 is associated with metastatic dissemination and a heightened risk of relapse, and preliminary observations in glioma and cervical cancer further suggest its potential contribution to tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‑small cell lung cancer (NSCLC), MELTF‑AS1 has been identified as an oncogenic driver. Its overexpression is closely linked with advanced tumor‑node‑metastasis stages, larger tumor size, and decreased survival. Functional analyses reveal that silencing MELTF‑AS1 in NSCLC cells significantly impairs proliferation, migration, and invasion—in part by relieving its negative regulation on miR‑1299. Further mechanistic studies indicate that copy number amplification and SP1‑driven transcriptional activation contribute to its high expression, while direct binding to the RNA‑binding protein YBX1 promotes phase separation and subsequent activation of ANXA8 transcription, reinforcing its tumorigenic role. These findings collectively underscore the promise of MELTF‑AS1 as a prognostic biomarker and a potential therapeutic target in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaofei Luo, Jinliang Wang, Xuan Wei, et al. 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