{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the studies directly mention METTL21EP, the provided abstracts describe in detail the functions of alpha‐catenin proteins—particularly the neural isoform, alpha N‐catenin—in regulating neuronal structure and function. In cultured hippocampal neurons, alpha N‐catenin is shown to stabilize dendritic spines by linking cadherin adhesion receptors to the actin cytoskeleton; loss of its function leads to increased spine motility and abnormal filopodial extensions, whereas its overexpression reduces spine turnover and augments synapse density."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, structural studies reveal that the overall conformation of alpha‐catenin comprises multiple domains that coordinate its interactions with adhesion proteins and the actin cytoskeleton. In its autoinhibited state, alpha‐catenin undergoes conformational changes under actomyosin-generated tension, a process that dynamically modulates vinculin recruitment to adherens junctions and ultimately fortifies cell–cell adhesion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to their roles in normal neural development, alpha‐catenins appear to have dual functions in disease contexts. In mouse models of intestinal tumorigenesis, for instance, simultaneous inactivation of alpha‐catenin and APC was found to suppress early adenoma formation—a finding that contrasts with its well‐established tumor suppressor role during late stages of colon cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough METTL21EP itself is not directly discussed in these abstracts, the diverse roles of alpha‐catenins in synaptic stabilization, cytoskeletal anchoring of adhesion complexes, neural lamination, axon guidance, and tumor initiation suggest that proteins operating in similar regulatory contexts may also contribute to the modulation of cell adhesion and signaling pathways. It is plausible that future investigations may reveal that METTL21EP, like alpha‐catenin family members, could play a supportive role in managing cytoskeletal dynamics and intercellular junction integrity.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kentaro Abe, Osamu Chisaka, Frans Van Roy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn1212"}], "href": "https://doi.org/10.1038/nn1212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15034585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15034585"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chankyu Park, William Falls, Jacqueline H Finger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng908"}], "href": "https://doi.org/10.1038/ng908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12089526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12089526"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chankyu Park, Jacqueline H Finger, Jonathan A Cooper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genesis (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gene.10024"}], "href": "https://doi.org/10.1002/gene.10024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11835672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11835672"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Masato Uemura, Masatoshi Takeichi "}, {"type": "b", "children": [{"type": "t", "text": "Alpha N-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20841"}], "href": "https://doi.org/10.1002/dvdy.20841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16691566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16691566"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Adam M Stocker, Anjen Chenn "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2005.12.057"}], "href": "https://doi.org/10.1016/j.brainres.2005.12.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16457793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16457793"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Itsuki Ajioka, Kazunori Nakajima "}, {"type": "b", "children": [{"type": "t", "text": "Switching of alpha-catenin from alphaE-catenin in the cortical ventricular zone to alphaN-catenin II in the intermediate zone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Dev Brain Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devbrainres.2005.08.004"}], "href": "https://doi.org/10.1016/j.devbrainres.2005.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16185771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16185771"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Noboru Ishiyama, Nobutoshi Tanaka, Kentaro Abe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.453928"}], "href": "https://doi.org/10.1074/jbc.M113.453928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23589308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23589308"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hiroyuki Shibata, Hiroshi Takano, Masaki Ito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alpha-catenin is essential in intestinal adenoma formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0705730104"}], "href": "https://doi.org/10.1073/pnas.0705730104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17989230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17989230"}]}]}]}