METTL25B Gene

Name	methyltransferase like 25B
Description	Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Mar 2025]
NCBI Gene ID	51093
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

METTL25B has 1,276 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.

Click the + buttons to view associations for METTL25B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

METTL25B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of METTL25B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of METTL25B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with METTL25B gene from the CellMarker Gene-Cell Type Associations dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of METTL25B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing METTL25B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with METTL25B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of METTL25B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of METTL25B gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with METTL25B gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of METTL25B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of METTL25B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	small molecule perturbations changing expression of METTL25B gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of METTL25B gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of METTL25B gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of METTL25B gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of METTL25B gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of METTL25B gene from the RummaGEO Gene Perturbation Signatures dataset.
	Sci-Plex Drug Perturbation Signatures	drug perturbations changing expression of METTL25B gene from the Sci-Plex Drug Perturbation Signatures dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of METTL25B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of METTL25B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with METTL25B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.