METTL26 Gene

Name	methyltransferase like 26
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe current study (PubMed:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "provides important insights into cholesterol metabolism by demonstrating that activation of liver X receptors (LXRs) in the mouse liver triggers mechanisms that promote cholesterol efflux and inhibit cholesterol biosynthesis. This dual action is mediated, at least in part, by the long non‐coding RNA LeXis, which is robustly induced under high dietary fat and cholesterol conditions or upon pharmacological LXR activation. LeXis appears to influence the expression of cholesterol biosynthetic genes by interacting with and modulating the DNA‐binding behavior of RALY, a transcriptional cofactor. However, despite the detailed elucidation of these pathways and mechanisms coordinating sterol homeostasis, the abstract does not provide any information or functional insights regarding METTL26. In summary, while the findings significantly enhance our understanding of lipid regulation via LXRs and non-coding RNAs, the role of METTL26 remains unaddressed in this context.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tamer Sallam, Marius C Jones, Thomas Gilliland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature17674"}], "href": "https://doi.org/10.1038/nature17674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27251289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27251289"}]}]}]}
NCBI Gene ID	84326
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

METTL26 has 1,696 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 26 datasets.

Click the + buttons to view associations for METTL26 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

METTL26 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of METTL26 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with METTL26 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with METTL26 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of METTL26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of METTL26 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with METTL26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of METTL26 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by METTL26 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with METTL26 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with METTL26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of METTL26 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with METTL26 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	IMPC Knockout Mouse Phenotypes	phenotypes of mice caused by METTL26 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of METTL26 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of METTL26 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	MGI Mouse Phenotype Associations 2023	phenotypes of transgenic mice caused by METTL26 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of METTL26 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of METTL26 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of METTL26 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of METTL26 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of METTL26 gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of METTL26 gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of METTL26 gene from the RummaGEO Gene Perturbation Signatures dataset.
	Sci-Plex Drug Perturbation Signatures	drug perturbations changing expression of METTL26 gene from the Sci-Plex Drug Perturbation Signatures dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of METTL26 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with METTL26 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.