{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that alternative splicing of the mitochondrial complex I gene NDUFV3 results in two distinct protein isoforms—NDUFV3-S and NDUFV3-L—that are incorporated into the multi‐subunit complex I in a tissue‐specific manner. In tissues such as heart and skeletal muscle only the short isoform is present, whereas in liver, brain, and lung the long isoform predominates, a difference that is paralleled by alterations in kinetic parameters, particularly substrate affinity, of complex I."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. Tincidunt vel sagittis quam convallis varius phasellus tincidunt. Libero ultrices libero fermentum lectus ex nunc felis. Turpis felis lectus feugiat sapien sagittis. Interdum diam tempor quisque lacinia lobortis libero. Posuere ex nam mi libero gravida aliquet donec. Ligula ultrices quisque rutrum odio leo pulvinar; dictumst hendrerit sollicitudin. Duis nisl gravida justo hendrerit eros sodales morbi."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Fusce class lectus fringilla commodo sit blandit pellentesque. Mattis sem magna metus luctus purus vivamus adipiscing ex. Pulvinar facilisis maximus dis fringilla consequat senectus viverra. It is important to note that although METTL27 is a gene of emerging interest in various biomedical contexts, the abstract provided does not contain any data or discussion regarding its function. Consequently, no conclusions about METTL27’s roles in cellular processes can be drawn from this study, underscoring the need for further investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sergio Guerrero-Castillo, Alfredo Cabrera-Orefice, Martijn A Huynen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and evolutionary analysis of tissue-specific isoforms of mitochondrial complex I subunit NDUFV3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Bioenerg (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2016.12.004"}], "href": "https://doi.org/10.1016/j.bbabio.2016.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27988283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27988283"}]}]}]}