{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMFSD2B functions as an essential sphingosine‐1‐phosphate (S1P) exporter in erythroid cells and platelets. Functional studies in an erythroid cell line have demonstrated that MFSD2B mediates the release of S1P—a lipid signaling molecule that regulates vascular permeability, immune cell trafficking, and platelet function. In platelets, MFSD2B‐dependent S1P export is necessary for aggregation and thrombus formation and contributes to intrinsic cardioprotection during myocardial infarction. These findings indicate that proper MFSD2B activity is crucial for maintaining plasma S1P levels and appropriate cardiovascular responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComparative sequence and structural analyses have revealed that MFSD2B is a member of the major facilitator superfamily, sharing a 12 transmembrane α‐helical domain structure with its close homolog MFSD2A. This evolutionary conservation suggests a common transport mechanism resembling bacterial Na⁺/melibiose symporters. Additionally, gene expression profiling studies have identified altered MFSD2B transcript levels in lung cancer subtypes, implying that MFSD2B—and related chromosome 2 genes—may serve as prognostic or diagnostic biomarkers in lung adenocarcinoma and other pulmonary malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, the multifaceted roles of MFSD2B—from regulating extracellular S1P homeostasis in erythrocytes and platelets to participating in cell signaling pathways that influence vascular integrity, cardioprotection, and potentially oncogenesis—highlight its importance in both physiological and pathological settings. As MFSD2B-mediated S1P transport appears intertwined with metabolic processes, cytoskeletal organization, and adaptive responses, targeting this transporter may offer new therapeutic opportunities in cardiovascular disease and cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naoki Kobayashi, Shoko Kawasaki-Nishi, Masato Otsuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-23300-x"}], "href": "https://doi.org/10.1038/s41598-018-23300-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29563527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29563527"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-023-38069-5"}], "href": "https://doi.org/10.1038/s41467-023-38069-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37100836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37100836"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shahrooz Ghaderi, Bodo Levkau "}, {"type": "b", "children": [{"type": "t", "text": "An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pharmthera.2023.108483"}], "href": "https://doi.org/10.1016/j.pharmthera.2023.108483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37390971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37390971"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Martin Angers, Marc Uldry, Dong Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20080165"}], "href": "https://doi.org/10.1042/BJ20080165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18694395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18694395"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lianmin Bao, Yong Zhang, Jian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-016-9343-z"}], "href": "https://doi.org/10.1007/s10565-016-9343-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27301951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27301951"}]}]}]}