{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMGAT3-AS1 is an intronic antisense long non-coding RNA derived from the MGAT3 gene, which plays a key role in the innate immune system. In the context of kidney transplantation, lower levels of MGAT3-AS1 measured in mononuclear cells were associated with delayed graft function, suggesting that the transcript may serve as a predictive biomarker for short‐term post‐transplant kidney outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSpecifically, lower preoperative and postoperative MGAT3-AS1 expression levels correlated with an increased risk of requiring dialysis within the first week after transplantation. The robust predictive performance—evidenced by a high negative predictive value—underscores the potential of MGAT3-AS1 to assist in early risk stratification and informs subsequent immunomodulatory strategies to mitigate allograft injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Subagini Nagarajah, Shengqiang Xia, Marianne Rasmussen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous intronic antisense long non-coding RNA, MGAT3-AS1, and kidney transplantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-51409-0"}], "href": "https://doi.org/10.1038/s41598-019-51409-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31611608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31611608"}]}]}]}