MIDEAS Gene

Name mitotic deacetylase associated SANT domain protein
Description Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed the existence of a novel mitotic deacetylase complex (MiDAC) whose activity is intertwined with the function of histone deacetylases (HDACs) in regulating chromatin structure. Using affinity capture coupled to quantitative mass spectrometry, researchers have demonstrated that MiDAC is one of several HDAC complexes targeted by selective inhibitors, and its identification has provided new insights into how HDAC inhibitors exert anti‐cancer and anti‐inflammatory effects while engaging megadalton‐sized complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDetailed analyses have shown that the interactions within these multiprotein complexes are highly selective: various HDAC inhibitors, including aminobenzamides and hydroxamates, differentially engage HDAC complexes, with MiDAC emerging as a distinct entity among them. This approach not only delineates the specific binding profiles of inhibitors against HDAC complexes but also emphasizes the importance of evaluating drug selectivity in the context of the complex's native assembly rather than isolated catalytic subunits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementing these findings, the identification of ELMSAN1 as a critical scaffolding protein within MiDAC has shed light on the complex’s biological functions during development. Studies using ELMSAN1 knockout mice and human-induced pluripotent stem cell models of cardiogenesis reveal that ELMSAN1 is essential for proper embryonic survival and heart formation, underscoring MiDAC’s pivotal role in early embryonic development and organogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marcus Bantscheff, Carsten Hopf, Mikhail M Savitski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Biotechnol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nbt.1759"}], "href": "https://doi.org/10.1038/nbt.1759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21258344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21258344"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-An Lu, Jiacheng Sun, Lu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.124.034816"}], "href": "https://doi.org/10.1161/JAHA.124.034816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38904247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38904247"}]}]}]}
NCBI Gene ID 91748
API
Download Associations
Predicted Functions View MIDEAS's ARCHS4 Predicted Functions.
Co-expressed Genes View MIDEAS's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIDEAS's ARCHS4 Predicted Functions.

Functional Associations

MIDEAS has 2,473 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 32 datasets.

Click the + buttons to view associations for MIDEAS from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIDEAS gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of MIDEAS gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Proteomics Cell lines associated with MIDEAS protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with MIDEAS gene from the CellMarker Gene-Cell Type Associations dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of MIDEAS gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing MIDEAS protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing MIDEAS protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with MIDEAS protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of MIDEAS protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by MIDEAS gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with MIDEAS gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
GlyGen Glycosylated Proteins ligands (chemical) binding MIDEAS protein from the GlyGen Glycosylated Proteins dataset.
GO Biological Process Annotations 2023 biological processes involving MIDEAS gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving MIDEAS gene from the curated GO Biological Process Annotations2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of MIDEAS gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of MIDEAS gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with MIDEAS gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of MIDEAS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of MIDEAS gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIDEAS gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of MIDEAS gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of MIDEAS gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of MIDEAS gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of MIDEAS gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of MIDEAS gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of MIDEAS gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of MIDEAS gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of MIDEAS gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of MIDEAS gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of MIDEAS protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of MIDEAS protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with MIDEAS protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.