{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMINAR1, also known as the major intrinsically disordered Notch2-associated receptor 1, is a unique protein characterized by a single transmembrane domain, a short cytoplasmic tail, and a predominantly unstructured extracellular region. It physically interacts with Notch2, thereby increasing the stability and function of the receptor. This interaction plays a crucial role in regulating angiogenesis, as MINAR1 negatively modulates new blood vessel formation—a function that has been demonstrated in cell culture, mouse matrigel plug assays, and zebrafish models. Notably, in normal tissues such as the breast epithelium, MINAR1 is highly expressed, while its downregulation in advanced breast cancer correlates with tumor progression, and its re-expression can inhibit tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther extending its role in disease, genetic studies in colorectal cancer have implicated MINAR1 in the regulation of tumor aggressiveness. Specific cis-regulatory variants that enhance MINAR1 expression have been associated with a poorer overall survival in colorectal cancer patients. Functional experiments revealed that elevated levels of MINAR1 may promote the epithelial–mesenchymal transition (EMT) process, while silencing MINAR1 leads to reduced migration, proliferation, and downregulation of key EMT and glycolysis genes in colorectal cancer cells. Together, these findings suggest that MINAR1 acts as a modulator of Notch signaling and contributes to tumor progression by facilitating EMT-related pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rachel Xi-Yeen Ho, Rosana D Meyer, Kevin B Chandler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjy002"}], "href": "https://doi.org/10.1093/jmcb/mjy002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29329397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29329397"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaofei Qu, Liqin Zhao, Mengyun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.33561"}], "href": "https://doi.org/10.1002/ijc.33561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33728681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33728681"}]}]}]}