{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that MINDY3 – a multifaceted protein that contains a caspase recruitment (CARD) domain, a nuclear receptor‐binding motif, and EF‐hand motifs – functions as a tumor suppressor by inducing cell death and inhibiting tumor cell growth. Overexpression of MINDY3 in various carcinoma cell lines led to significant apoptosis and reduced proliferation, suggesting that its structural domains enable it to engage in apoptotic signaling pathways that may be critical for controlling cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther investigation into MINDY3’s mechanism of action has demonstrated that it enforces cell cycle arrest at the G1 phase. By modulating key cell‐cycle regulators—such as cyclin E, CDK2, and the cyclin-dependent kinase inhibitor p27—and by physically interacting with proteins like JAB1, MINDY3 impedes the translocation of p27 from the nucleus to the cytoplasm. Such interactions contribute to its ability to suppress cell motility and anchorage-independent growth, thereby reinforcing its tumor‐suppressive role particularly in non-small cell lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its established roles in apoptosis and cell cycle regulation, the broader regulatory networks involving MINDY3 are of emerging interest. Investigations into ovarian cancer have highlighted the importance of regulatory RNAs—including circular RNAs such as circFAM188A—that modulate proliferation, autophagy, and invasion. Although the study focused on circFAM188A, these findings underscore a complex milieu where proteins like MINDY3 may interconnect with autophagic and invasion pathways, suggesting additional layers through which tumor suppression may be coordinated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Baohua Liu, Yuqing Liu, Jingzhou Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARP is a novel caspase recruitment domain containing pro-apoptotic protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0006-291X(02)00379-0"}], "href": "https://doi.org/10.1016/S0006-291X(02"}, {"type": "t", "text": "00379-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12054670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12054670"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fang Lu, Jian-Xin Xue, Yu-Chang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CARP is a potential tumor suppressor in gastric carcinoma and a single-nucleotide polymorphism in CARP gene might increase the risk of gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0097743"}], "href": "https://doi.org/10.1371/journal.pone.0097743"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24870804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24870804"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Y Shi, J Chen, Z Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "C10ORF97 is a novel tumor-suppressor gene of non-small-cell lung cancer and a functional variant of this gene increases the risk of non-small-cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.116"}], "href": "https://doi.org/10.1038/onc.2011.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21499297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21499297"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Min Yong, Yuhua Zeng, Yuqin Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in Epithelial Ovarian Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Rep (Hoboken) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cnr2.2128"}], "href": "https://doi.org/10.1002/cnr2.2128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39229655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39229655"}]}]}]}