{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that MIR100—which encodes microRNA‐100—plays critical roles in intercellular communication and therapeutic response. In several tumor models including breast, colorectal, lung, and pancreatic cancers, MIR100 is transferred via exosomes or coordinately induced as part of a long non‐coding host transcript (MIR100HG) in response to TGF‐β signaling. Such RNA‐mediated intercellular transfer modulates cell cycle distribution and drug‐induced apoptosis, thereby contributing to acquired chemoresistance and a more aggressive tumor phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctionally, MIR100 predominantly exerts tumor‐suppressive effects in a range of solid tumors by post‐transcriptionally regulating key oncogenic pathways. Restoration of MIR100 expression suppresses cell proliferation, promotes apoptosis, and impairs migration and invasion—thereby improving sensitivity to cytotoxic agents. These outcomes are largely mediated through direct targeting of molecules such as mTOR, Polo‐like kinase 1 (PLK1), insulin‐like growth factor receptors, HOXA1, BMPR2, and components of the Wnt/β‐catenin pathway, resulting in alterations in cell cycle progression and diminished tumor aggressiveness. In diverse cancers including prostate, ovarian, hepatocellular, and lung carcinomas, decreased MIR100 levels have been correlated with advanced stage disease and poorer clinical outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its direct effects on tumor cell proliferation and survival, MIR100 is implicated in the regulation of cancer stem cell self‐renewal, differentiation, and metastatic spread. Embedded within MIR100HG transcripts, its biogenesis is subject to additional layers of regulation via competing endogenous RNAs—such as circular RNAs and long non‐coding RNAs—that sequester MIR100 and modulate its availability. Furthermore, alterations in circulating MIR100 levels have shown promise as non‐invasive biomarkers for early diagnosis and for prognostic stratification in several malignancies (e.g., gastric, bladder and pediatric cancers) as well as in non‐malignant contexts like wound healing and inflammatory injury. These multifaceted roles underscore MIR100’s potential as both a mechanistic target and a biomarker in cancer management."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei-xian Chen, Xue-min Liu, Meng-meng Lv, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-03962-x"}], "href": "https://doi.org/10.1038/s41467-018-03962-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748571"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Shi, Nehad M Alajez, Carlo Bastianutto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24880"}], "href": "https://doi.org/10.1002/ijc.24880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19739117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19739117"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ankur K Nagaraja, Chad J Creighton, Zhifeng Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2009-0295"}], "href": "https://doi.org/10.1210/me.2009-0295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20081105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20081105"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "V Boni, R Zarate, J C Villa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tpj.2010.58"}], "href": "https://doi.org/10.1038/tpj.2010.58"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20585341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20585341"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wooi Loon Ng, Dan Yan, Xiangming Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2010.08.007"}], "href": "https://doi.org/10.1016/j.dnarep.2010.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20869334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20869334"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dandan Sun, Yong Sun Lee, Ankit Malhotra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-1031"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-1031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21212412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21212412"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Y-S Zheng, H Zhang, X-J Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.208"}], "href": "https://doi.org/10.1038/onc.2011.208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21643017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21643017"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Bing Feng, Rui Wang, Long-Bang Chen "}, {"type": "b", "children": [{"type": "t", "text": "MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2011.11.024"}], "href": "https://doi.org/10.1016/j.canlet.2011.11.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22120675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22120675"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dong-Xian Peng, Min Luo, Li-Wen Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic implications of microRNA-100 and its functional roles in human epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.1625"}], "href": "https://doi.org/10.3892/or.2012.1625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22246341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22246341"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "A Petrelli, A Perra, K Schernhuber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.631"}], "href": "https://doi.org/10.1038/onc.2011.631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22249248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22249248"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yang Zeng, Xuebin Qu, Hongling Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.05.049"}], "href": "https://doi.org/10.1016/j.febslet.2012.05.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22684006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22684006"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Anna Torres, Kamil Torres, Anna Pesci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-12-369"}], "href": "https://doi.org/10.1186/1471-2407-12-369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22920721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22920721"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "C A Gebeshuber, J Martinez "}, {"type": "b", "children": [{"type": "t", "text": "miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.372"}], "href": "https://doi.org/10.1038/onc.2012.372"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22926517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22926517"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Angeline A Giangreco, Avani Vaishnav, Dennis Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor microRNAs, miR-100 and -125b, are regulated by 1,25-dihydroxyvitamin D in primary prostate cells and in patient tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Prev Res (Phila) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1940-6207.CAPR-12-0253"}], "href": "https://doi.org/10.1158/1940-6207.CAPR-12-0253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23503652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23503652"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Dahu Chen, Yutong Sun, Yuan Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1004177"}], "href": "https://doi.org/10.1371/journal.pgen.1004177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24586203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24586203"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yi-Yuan Ge, Qing Shi, Zhi-Yuan Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-100 promotes the autophagy of hepatocellular carcinoma cells by inhibiting the expression of mTOR and IGF-1R."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2189"}], "href": "https://doi.org/10.18632/oncotarget.2189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25026290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25026290"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yi Gong, Tianliang He, Lu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of miR-100 in regulating apoptosis of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep11650"}], "href": "https://doi.org/10.1038/srep11650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26130569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26130569"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Qian Jiang, Miao He, Shu Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4342-x"}], "href": "https://doi.org/10.1007/s13277-015-4342-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26537584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26537584"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Baotong Zhang, Ranran Zhao, Yuan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6790"}], "href": "https://doi.org/10.18632/oncotarget.6790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26744318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26744318"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jessica Clague, Scott M Lippman, Hushan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in MicroRNA genes and risk of oral premalignant lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.20588"}], "href": "https://doi.org/10.1002/mc.20588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19851984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19851984"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Bao Hua Li, Jian Song Zhou, Feng Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced miR-100 expression in cervical cancer and precursors and its carcinogenic effect through targeting PLK1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2011.04.037"}], "href": "https://doi.org/10.1016/j.ejca.2011.04.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21636267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21636267"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Dawoon E Jung, Jing Wen, Taeyun Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differentially expressed microRNAs in pancreatic cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pancreas (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPA.0b013e318221b33e"}], "href": "https://doi.org/10.1097/MPA.0b013e318221b33e"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21785383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21785383"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jaqueline Carvalho de Oliveira, Carlos Alberto Scrideli, María Sol Brassesco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential miRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2011.10.005"}], "href": "https://doi.org/10.1016/j.leukres.2011.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22099053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22099053"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yi Jin, Stéphanie D Tymen, Dan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-99 family targets AKT/mTOR signaling pathway in dermal wound healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0064434"}], "href": "https://doi.org/10.1371/journal.pone.0064434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23724047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23724047"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "F Akbari Moqadam, E A M Lange-Turenhout, I M Ariës, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2013.06.027"}], "href": "https://doi.org/10.1016/j.leukres.2013.06.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23915977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23915977"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "X-J Li, X-Q Luo, B-W Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2013.562"}], "href": "https://doi.org/10.1038/bjc.2013.562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24030073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24030073"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Faman Xiao, Yifeng Bai, Zhenzhu Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2014.01.024"}], "href": "https://doi.org/10.1016/j.ejca.2014.01.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24559685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24559685"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Min Wang, Dong Ren, Wei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of miR-100 enhances migration, invasion, epithelial-mesenchymal transition and stemness properties in prostate cancer cells through targeting Argonaute 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2413"}], "href": "https://doi.org/10.3892/ijo.2014.2413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24805183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24805183"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Lu Deng, Li Shang, Shoumin Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-3710"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-3710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25217527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25217527"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Hui Wang, Lei Wang, Zheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three dysregulated microRNAs in serum as novel biomarkers for gastric cancer screening."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-014-0298-8"}], "href": "https://doi.org/10.1007/s12032-014-0298-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25367852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25367852"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Chu Qin, Ru-Yi Huang, Zhao-Xia Wang "}, {"type": "b", "children": [{"type": "t", "text": "Potential role of miR-100 in cancer diagnosis, prognosis, and therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3267-8"}], "href": "https://doi.org/10.1007/s13277-015-3267-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25740059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25740059"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Johannes Denk, Kai Boelmans, Christine Siegismund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0126423"}], "href": "https://doi.org/10.1371/journal.pone.0126423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25992776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25992776"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Chen Li, Yanping Gao, Kai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple Roles of MicroRNA-100 in Human Cancer and its Therapeutic Potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000438572"}], "href": "https://doi.org/10.1159/000438572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26606597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26606597"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Elisabetta Vergani, Lorenza Di Guardo, Matteo Dugo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6599"}], "href": "https://doi.org/10.18632/oncotarget.6599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26684239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26684239"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Tarek Kamal Motawi, Sherine Maher Rizk, Taghreed Mahmoud Ibrahim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating microRNAs, miR-92a, miR-100 and miR-143, as non-invasive biomarkers for bladder cancer diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.3171"}], "href": "https://doi.org/10.1002/cbf.3171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26916216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26916216"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Hui-Chao Zhou, Jian-Hong Fang, Li-Ru Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs miR-125b and miR-100 suppress metastasis of hepatocellular carcinoma by disrupting the formation of vessels that encapsulate tumour clusters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4804"}], "href": "https://doi.org/10.1002/path.4804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27577856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27577856"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Katayoon Pakravan, Sadegh Babashah, Majid Sadeghizadeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-017-0335-7"}], "href": "https://doi.org/10.1007/s13402-017-0335-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28741069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28741069"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Meihan Liu, Tao Han, Shaomin Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA HAGLROS regulates cell apoptosis and autophagy in lipopolysaccharides-induced WI-38 cells via modulating miR-100/NF-κB axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.109"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29673591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29673591"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Qinyu Sun, Vidisha Tripathi, Je-Hyun Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky696"}], "href": "https://doi.org/10.1093/nar/gky696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30102375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30102375"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Yijun Shi, Zizhang Guo, Na Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa_circ_0006168 sponges miR-100 and regulates mTOR to promote the proliferation, migration and invasion of esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109151"}], "href": "https://doi.org/10.1016/j.biopha.2019.109151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31229921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31229921"}]}]}]}