{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐103 (including its isoform miR‑103a‑3p, commonly known as MIR103A1) is emerging as a multifunctional regulator in cancer. In several tumor types—including colorectal cancer, gastric cancer, prostate cancer, bladder cancer, hepatocellular carcinoma, triple‐negative breast cancer, glioma, and non‑small cell lung cancer—it can be overexpressed or underexpressed, thereby influencing tumor proliferation, metastasis, and stemness. For example, miR‑103 promotes colorectal cancer cell proliferation and migration by targeting the tumor suppressors DICER and PTEN, and in gastric cancer, its high expression correlates with poor survival via suppression of KLF4. In bladder cancer, a circular RNA acts as a “sponge” to sequester miR‑103a‑3p, modulating CDK6‐mediated proliferation. Moreover, in hepatocellular carcinoma and other solid tumors, miR‑103 has been implicated in promoting epithelial–mesenchymal transition through targeting key regulators such as LATS2, while in leukemia its induction sensitizes cells to glucocorticoid‑induced apoptosis through complex downstream effects. These studies underscore the dualistic oncogenic and tumor‐suppressive roles of MIR103A1 depending on the cellular context."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in oncogenesis, MIR103A1 is intimately involved in the regulation of metabolic, cardiovascular, inflammatory, and neurological processes. Aberrant miR‑103 expression has been linked to metabolic disorders such as insulin resistance, type 2 diabetes, and polycystic ovary syndrome, while altered circulating levels associate with Alzheimer’s disease and autism spectrum disorder. In vascular and cardiac contexts, miR‑103a‑3p modulates endothelial function and inflammatory responses—for instance, by repressing SNRK in glomerular endothelial cells to promote AngII‑induced renal inflammation, and by affecting BNIP3‐mediated autophagic flux under oxidative stress thereby influencing pyroptosis in endothelial cells. In addition, its capacity to dampen inflammatory signaling (for example, through targeting TBL1XR1) and to regulate chemokine expression (via CXCL12 in thrombosis) highlights a significant role in immune regulation and even in limiting HIV‑1 entry through downregulation of the CCR5 coreceptor."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIR103A1 also contributes to the fine‐tuning of basic cellular processes including cell cycle control, autophagy, and the maintenance of stem cell attributes. In epithelial stem cell niches, the miR‑103/107 family regulates quiescence and proliferation by targeting kinases such as p90RSK2, while also coordinating end‐stage autophagy to prevent aberrant macropinocytosis. In cancer, these molecules promote stem‑like features and a sustained activation of pathways such as Wnt/β‑catenin by targeting negative regulators like Axin2. Altogether, these findings reveal a broad functional spectrum for MIR103A1—from modulating cell–cell communication and metabolic homeostasis to impacting the progression and therapy response of diverse diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Geng, Bing Sun, Bo Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms15058458"}], "href": "https://doi.org/10.3390/ijms15058458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24828205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24828205"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ye Zhang, Xiujuan Qu, Ce Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2835-7"}], "href": "https://doi.org/10.1007/s13277-014-2835-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25407491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25407491"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoliang Fu, Wei Zhang, Yansheng Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-103 suppresses tumor cell proliferation by targeting PDCD10 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.23143"}], "href": "https://doi.org/10.1002/pros.23143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26771762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26771762"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhenyu Zhong, Mengxin Lv, Junxia Chen "}, {"type": "b", "children": [{"type": "t", "text": "Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep30919"}], "href": "https://doi.org/10.1038/srep30919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27484176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27484176"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shlomit Kfir-Erenfeld, Noa Haggiag, Moshe Biton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13447"}], "href": "https://doi.org/10.18632/oncotarget.13447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27888798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27888798"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bin Xiong, Xuefeng Lei, Lei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-103 regulates triple negative breast cancer cells migration and invasion through targeting olfactomedin 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.02.028"}], "href": "https://doi.org/10.1016/j.biopha.2017.02.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28320108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28320108"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jie Zheng, Yuzhen Liu, Yanchun Qiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-103 Promotes Proliferation and Metastasis by Targeting KLF4 in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18050910"}], "href": "https://doi.org/10.3390/ijms18050910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28445396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28445396"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ling Wang, Ying Liu, Jianwei Song "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-103 suppresses glioma cell proliferation and invasion by targeting the brain-derived neurotrophic factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.8282"}], "href": "https://doi.org/10.3892/mmr.2017.8282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29257320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29257320"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "D-S Wang, B Zhong, M-S Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of serum miR-103 predicts unfavorable prognosis in patients with colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201807_15506"}], "href": "https://doi.org/10.26355/eurrev_201807_15506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30058684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30058684"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Zhongyi Fan, Jing Yang, Dong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The risk variant rs884225 within EGFR impairs miR-103a-3p's anti-tumourigenic function in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0576-6"}], "href": "https://doi.org/10.1038/s41388-018-0576-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30470824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30470824"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wenjie Chen, Gan Yao, Keqin Zhou "}, {"type": "b", "children": [{"type": "t", "text": "miR-103a-2-5p/miR-30c-1-3p inhibits the progression of prostate cancer resistance to androgen ablation therapy via targeting androgen receptor variant 7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28680"}], "href": "https://doi.org/10.1002/jcb.28680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30963631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30963631"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tao Sun, Peng Yang, Yunbin Gao "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/EP087847"}], "href": "https://doi.org/10.1113/EP087847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31645082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31645082"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yahui She, Yuanyuan Han, Guangting Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergen.2019.12.004"}], "href": "https://doi.org/10.1016/j.cancergen.2019.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31962276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31962276"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Min Fu, Chu-Wen Chen, Lin-Qian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑103a‑3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2020.5069"}], "href": "https://doi.org/10.3892/ijo.2020.5069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32467999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32467999"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuling Liu, Yuanzhou Zhang, Bowen Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-103a promotes tumour growth and influences glucose metabolism in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03905-3"}], "href": "https://doi.org/10.1038/s41419-021-03905-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34131101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34131101"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Haixun Li, Muren Huhe, Jiaxin Lou "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-103a-3p Promotes Cell Proliferation and Invasion in Non-Small-Cell Lung Cancer Cells through Akt Pathway by Targeting PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/7590976"}], "href": "https://doi.org/10.1155/2021/7590976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34307670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34307670"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jiaqi Yao, Tom Hennessey, Alex Flynt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-related cofilin abnormality in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0015546"}], "href": "https://doi.org/10.1371/journal.pone.0015546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21179570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21179570"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mora Murri, María Insenser, Elena Fernández-Durán, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of polycystic ovary syndrome (PCOS), sex hormones, and obesity on circulating miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2013-2218"}], "href": "https://doi.org/10.1210/jc.2013-2218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24037889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24037889"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Johannes Denk, Kai Boelmans, Christine Siegismund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA Profiling of CSF Reveals Potential Biomarkers to Detect Alzheimer`s Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0126423"}], "href": "https://doi.org/10.1371/journal.pone.0126423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25992776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25992776"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Qian Xu, Ying Li, Yong-Fang Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-103: molecular link between insulin resistance and nonalcoholic fatty liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v21.i2.511"}], "href": "https://doi.org/10.3748/wjg.v21.i2.511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25593466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25593466"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Fengzhen Huang, Zhe Long, Zhao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0129052"}], "href": "https://doi.org/10.1371/journal.pone.0129052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26061495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26061495"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lingzhi Huang, Lezhi Li, Xiaofang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-103a targeting Piezo1 is involved in acute myocardial infarction through regulating endothelium function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiol J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5603/CJ.a2016.0056"}], "href": "https://doi.org/10.5603/CJ.a2016.0056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27515482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27515482"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Qiulun Lu, Zejun Ma, Ye Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-10116-0"}], "href": "https://doi.org/10.1038/s41467-019-10116-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31086184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31086184"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jie Wang, Chunyan Chen, Yun Zhang "}, {"type": "b", "children": [{"type": "t", "text": "An investigation of microRNA-103 and microRNA-107 as potential blood-based biomarkers for disease risk and progression of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23006"}], "href": "https://doi.org/10.1002/jcla.23006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31420923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31420923"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Mao Luo, Chunrong Xu, Yulin Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-103 family as potential biomarkers for type 2 diabetes through targeting CAV-1 and SFRP4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Diabetol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00592-019-01430-6"}], "href": "https://doi.org/10.1007/s00592-019-01430-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31583475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31583475"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Shaoliang Sun, Shanyi Chai, Feng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed microRNA-103a-3p inhibits acute lower-extremity deep venous thrombosis via inhibition of CXCL12."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2168"}], "href": "https://doi.org/10.1002/iub.2168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31613419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31613419"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yiran Wang, Xianjing Song, Zhibo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-103 Protects Coronary Artery Endothelial Cells against H"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-Induced Oxidative Stress via BNIP3-Mediated End-Stage Autophagy and Antipyroptosis Pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8351342"}], "href": "https://doi.org/10.1155/2020/8351342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32190178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32190178"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Robert Lodge, Nicolas Bellini, Mélanie Laporte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mBio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/mBio.02314-20"}], "href": "https://doi.org/10.1128/mBio.02314-20"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32994328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32994328"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ruina Li, Pengbo Liang, Juan Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal miR-103a-3p ameliorates lipopolysaccharide-induced immune response in BEAS-2B cells via NF-κB pathway by targeting transducin β-like 1X related protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.13241"}], "href": "https://doi.org/10.1111/1440-1681.13241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31876003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31876003"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Jiexia Ding, Caixia Xia, Panpan Cen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-103-3p promotes hepatic steatosis to aggravate nonalcoholic fatty liver disease by targeting of ACOX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-022-07515-w"}], "href": "https://doi.org/10.1007/s11033-022-07515-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35606603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35606603"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Han Peng, Jong Kook Park, Julia Katsnelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-103/107 Family Regulates Multiple Epithelial Stem Cell Characteristics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.1962"}], "href": "https://doi.org/10.1002/stem.1962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25639731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25639731"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Damon Polioudakis, Nathan S Abell, Vishwanath R Iyer "}, {"type": "b", "children": [{"type": "t", "text": "miR-503 represses human cell proliferation and directly targets the oncogene DDHD2 by non-canonical target pairing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-015-1279-9"}], "href": "https://doi.org/10.1186/s12864-015-1279-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25653011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25653011"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Jong Kook Park, Han Peng, Julia Katsnelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs-103/107 coordinately regulate macropinocytosis and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201604032"}], "href": "https://doi.org/10.1083/jcb.201604032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27872138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27872138"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Hsin-Yi Chen, Yaw-Dong Lang, Han-Nan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-41053-z"}], "href": "https://doi.org/10.1038/s41598-019-41053-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31273221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31273221"}]}]}]}