{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR103B2 is a microRNA that regulates gene expression by binding to specific mRNA targets and thereby modulating their translation. In the context of colorectal cancer, MIR103B2 (often noted as miR‑103) is up‐regulated and functions as an oncogene by targeting and downregulating tumor suppressor genes such as DICER and PTEN. This action promotes cell proliferation and migration, suggesting that aberrant expression of MIR103B2 contributes to tumor progression and may serve as both a biomarker and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in oncogenesis, MIR103B2 has been implicated in metabolic regulation. Studies investigating its association with insulin resistance and nonalcoholic fatty liver disease (NAFLD) indicate that altered levels of MIR103B2 correlate with disturbances in lipid and glucose metabolism. These findings suggest that MIR103B2 may influence systemic metabolic homeostasis and contribute to the pathogenesis of metabolic disorders, underscoring its significance as a multifaceted regulator in both cancer biology and metabolic disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Geng, Bing Sun, Bo Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms15058458"}], "href": "https://doi.org/10.3390/ijms15058458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24828205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24828205"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qian Xu, Ying Li, Yong-Fang Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-103: molecular link between insulin resistance and nonalcoholic fatty liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v21.i2.511"}], "href": "https://doi.org/10.3748/wjg.v21.i2.511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25593466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25593466"}]}]}]}