{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐105 has emerged as a multifaceted regulator in cancer biology. In the tumor microenvironment, cancer cells—most notably in breast cancer—secrete miR‐105 via extracellular vesicles to reprogram stromal fibroblasts. This reprogramming alters cellular metabolism, enhancing nutrient utilization and waste detoxification to sustain tumor growth. In parallel, miR‐105 produced as part of a cancer‐germline transcript has been shown to disrupt vascular endothelial barriers, thereby facilitating metastasis, while similar extracellular vesicle–mediated mechanisms re‐prioritize mRNA translation pathways under nutrient fluctuations."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its effects on the tumor niche, miR‐105 can function in a cell‐intrinsic manner as a tumor suppressor in several cancers. In prostate cancer, for instance, reduced levels of miR‐105 are associated with enhanced proliferation and invasiveness, with its restoration leading to significant inhibition of oncogenic properties. Similar tumor‐suppressive roles are observed in gastric and esophageal carcinomas, and in specific breast and ovarian cancers, where diminished miR‐105 expression correlates with aggressive disease and chemoresistance. Mechanistically, miR‐105 targets critical mediators such as CDK6, SOX9, and ZNRF2, thereby modulating cell cycle progression, differentiation, and drug sensitivity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncogenic and tumor‐suppressive roles, miR‐105 also influences differentiation pathways in both normal and diseased states. It acts as a potent enhancer of megakaryopoiesis during hematopoietic differentiation by targeting transcription factors such as c‐Myb. In stem cell models, miR‐105 promotes osteogenic differentiation through modulation of SOX9, and in osteosarcoma, its 5p‐variant is integrated into a regulatory axis—modulated by circular RNAs—that controls FOXO1 expression, affecting cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Axelle Loriot, Aurélie Van Tongelen, Jordi Blanco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.29628"}], "href": "https://doi.org/10.4161/epi.29628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25089631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25089631"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Yan, Xiwei Wu, Weiying Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-018-0083-6"}], "href": "https://doi.org/10.1038/s41556-018-0083-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29662176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29662176"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Miranda Y Fong, Wei Yan, Majid Ghassemian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.202051239"}], "href": "https://doi.org/10.15252/embr.202051239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33345445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33345445"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "D Rice Honeywell, Miguel A Cabrita, Huijun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-105 inhibits prostate tumour growth by suppressing CDK6 levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0070515"}], "href": "https://doi.org/10.1371/journal.pone.0070515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23950948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23950948"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Jin, G-W Zhang, C-L Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of miRNA-105 inhibits the progression of gastric carcinoma by directly targeting SOX9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201905_17804"}], "href": "https://doi.org/10.26355/eurrev_201905_17804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31115004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31115004"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "J-C Shang, G-Z Yu, Z-W Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-105 inhibits gastric cancer cells metastasis, epithelial-mesenchymal transition by targeting SOX9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201907_18429"}], "href": "https://doi.org/10.26355/eurrev_201907_18429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31364116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31364116"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ruixiang Gao, Zhen Wang, Qiang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-105 plays an independent prognostic role in esophageal cancer and acts as an oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-180"}], "href": "https://doi.org/10.3233/CBM-180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31796663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31796663"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Bo Lin, Chunhua Liu, Enyi Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-105-3p acts as an oncogene to promote the proliferation and metastasis of breast cancer cells by targeting GOLIM4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-07909-2"}], "href": "https://doi.org/10.1186/s12885-021-07909-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33722196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33722196"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mao Li, Shun Zhang, Yuan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of hsa‑miR‑105 during the pathogenesis of paclitaxel resistance and its clinical implication in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8035"}], "href": "https://doi.org/10.3892/or.2021.8035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33846814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33846814"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Viraj Kamat, Prasuna Paluru, Melissa Myint, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA screen of human embryonic stem cell differentiation reveals miR-105 as an enhancer of megakaryopoiesis from adult CD34+ cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.1640"}], "href": "https://doi.org/10.1002/stem.1640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24446170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24446170"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chun-Liang Li, Kai Wang, Zhao-Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-105 enhances osteogenic differentiation of hADSCs via the targeted regulation of SOX9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2021.101540"}], "href": "https://doi.org/10.1016/j.tice.2021.101540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33838353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33838353"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Chunshan Jiang, Zhe Jiang, Xuewu Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.206022"}], "href": "https://doi.org/10.18632/aging.206022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39103205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39103205"}]}]}]}