MIR10A Gene

HGNC Family Non-coding RNAs
Name microRNA 10a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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Mechanistically, miR‑10a has been shown to directly target tumor suppressors (for example, PTEN, CHL1, EphA4) and may also affect additional pathways (including AKT/ERK signalling and regulation of transcription factors) to either promote or, in some contexts, restrict tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn developmental contexts and during cell differentiation, miR‑10a (often discussed as a member of the miR‑10 family) plays a critical role. Its expression is prominently induced by retinoic acid in neuroblastoma cells, thereby promoting neural differentiation through direct targeting of regulatory molecules such as NCOR2 and the splicing factor SFRS1. In parallel, reduced miR‑10a expression in aged human mesenchymal stem cells contributes to diminished differentiation capacity—a defect that can be partly rescued by restoring miR‑10a levels via down‑regulation of the transcription factor KLF4. Moreover, region‑specific expression studies in human neural progenitors have implicated miR‑10 in establishing hindbrain and spinal cord identity, and in granulosa cells, miR‑10a helps to coordinate cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncogenesis and development, miR‑10a is emerging as a promising diagnostic and therapeutic target in diverse clinical settings. Its kidney‑enriched expression and subsequent release into urine have been exploited for the sensitive detection of renal injury, while in airway smooth muscle cells, miR‑10a directly inhibits PI3K pathway components to control cell proliferation. Hormonal modulation and epigenetic regulation of miR‑10a have also been noted in breast cancer and bladder cancer, respectively. Moreover, miR‑10a contributes to chemoresistance in pancreatic cancer and is involved in the regulation of inflammatory signaling—partly via its targeting of TBX5—as well as in intercellular communication through mesenchymal stem cell‑derived exosomes. 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Synonyms MIR-10A, HSA-MIR-10A, MIRN10A, MIRNA10A
NCBI Gene ID 406902
API
Download Associations
Predicted Functions View MIR10A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR10A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR10A's ARCHS4 Predicted Functions.

Functional Associations

MIR10A has 1,486 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 24 datasets.

Click the + buttons to view associations for MIR10A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR10A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR10A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR10A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with MIR10A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR10A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR10A gene/protein from the curated CTD Gene-Disease Associations dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with MIR10A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR10A gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR10A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR10A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR10A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR10A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR10A from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR10A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR10A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR10A gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR10A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR10A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by MIR10A gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR10A gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by MIR10A gene mutations from the MPO Gene-Phenotype Associations dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR10A gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with MIR10A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
WikiPathways Pathways 2014 pathways involving MIR10A protein from the Wikipathways Pathways 2014 dataset.