MIR1182 Gene

HGNC Family Non-coding RNAs
Name microRNA 1182
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‑1182 functions predominantly as a tumor suppressor by post‑transcriptionally regulating key oncogenic factors. In gastric cancer, miR‑1182 directly binds to a specific region in the open reading frame of hTERT mRNA to reduce hTERT protein levels, thereby inhibiting cancer cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in bladder cancer, miR‑1182 targets the 3′‑UTR of hTERT mRNA to induce cell cycle arrest and apoptosis, enhance chemosensitivity to cisplatin, and suppress tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several malignancies, oncogenic circular RNAs exert their effects by sponging miR‑1182, thereby alleviating its inhibitory influence on downstream targets. In prostate cancer, the up‑regulated circABCC4 sequesters miR‑1182, leading to enhanced FOXP4 expression and promotion of malignant behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In non‑small cell lung cancer (NSCLC), both circ_0000735 and circ_0067934 have been shown to bind miR‑1182; circ_0000735 acts in this manner to facilitate cell proliferation, migration, and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while circ_0067934 sponging of miR‑1182 results in the upregulation of KLF8, further driving NSCLC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in another NSCLC study, circCAMSAP1 was found to directly bind miR‑1182, thereby relieving the suppression of survivin (BIRC5) and promoting tumor cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these, in pancreatic cancer, miR‑1182 is negatively regulated by the oncogenic circ‑0050102. Downregulation of miR‑1182 leads to the derepression of its target NPSR1, which in turn facilitates pancreatic tumor cell proliferation, migration, invasion, and overall malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dan Zhang, Yu-Feng Xiao, Jian-Wei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.01.044"}], "href": "https://doi.org/10.1016/j.canlet.2015.01.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25662441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25662441"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Zhou, Wenbin Dai, Jianming Song "}, {"type": "b", "children": [{"type": "t", "text": "miR-1182 inhibits growth and mediates the chemosensitivity of bladder cancer by targeting hTERT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.01.014"}], "href": "https://doi.org/10.1016/j.bbrc.2016.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26772886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26772886"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Changkun Huang, Huanghao Deng, Yinhuai Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circABCC4 as the ceRNA of miR-1182 facilitates prostate cancer progression by promoting FOXP4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14477"}], "href": "https://doi.org/10.1111/jcmm.14477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31270953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31270953"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Li, Wei Jiang, Tongmiao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced expression of circ_0000735 forecasts clinical severity in NSCLC and promotes cell progression via sponging miR-1179 and miR-1182."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.01.134"}], "href": "https://doi.org/10.1016/j.bbrc.2019.01.134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737027"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Min Zhao, Wei Ma, Chaonan Ma "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2020.110461"}], "href": "https://doi.org/10.1016/j.biopha.2020.110461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32768951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32768951"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yunfei Wang, Xiaobo Li, Huaqi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircCAMSAP1 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis by sponging miR-1182 and regulating BIRC5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2011639"}], "href": "https://doi.org/10.1080/21655979.2021.2011639"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35132928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35132928"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Surong Hua, Junyi Gao, Tong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgaa130"}], "href": "https://doi.org/10.1093/carcin/bgaa130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33289016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33289016"}]}]}]}
Synonyms HSA-MIR-1182, MIRN1182
NCBI Gene ID 100302132
API
Download Associations
Predicted Functions View MIR1182's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1182's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1182's ARCHS4 Predicted Functions.

Functional Associations

MIR1182 has 969 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for MIR1182 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1182 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1182 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR1182 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1182 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1182 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1182 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1182 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR1182 from the GeneSigDB Published Gene Signatures dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1182 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR1182 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR1182 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1182 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR1182 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR1182 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1182 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.