{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies in non‐small cell lung cancer revealed that miR‑1183 is a critical mediator of oncogenic signaling. In this context, the circRNA hsa_circ_0004015 was shown to act as a sponge for miR‑1183, thereby attenuating its inhibitory effect on its downstream target PDPK1, which in turn promoted cell proliferation, invasion, and drug resistance to tyrosine kinase inhibitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in papillary thyroid carcinoma and breast cancer, distinct circular RNAs (circ_0005273 and hsa_circ_0000851, respectively) sequestered miR‑1183 to relieve repression of key oncogenic drivers (SOX2 in thyroid cancer and PDK1 in breast cancer), enhancing tumor growth and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cardiovascular settings, miR‑1183 appears to serve as an important biomarker and regulatory molecule. Microarray analyses conducted in patients with rheumatic heart disease demonstrated that miR‑1183 is markedly upregulated, with its differential expression correlated with secondary pulmonary arterial hypertension and potentially reflecting pulmonary artery remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, human atrial myocardium exposed to stretch and tachycardia showed a substantial, up to fourfold, increase in miR‑1183 expression concomitant with the downregulation of its predicted targets, ADAM20 and PLA2G7. This pattern was further observed in chronic remodeling of atrial fibrillation and dilated cardiomyopathy hearts, underscoring its broader functional significance in cardiac remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings highlight that miR‑1183 functions as an essential regulatory microRNA whose activity is modulated through competitive endogenous RNA interactions. By being sequestered by various circRNAs in different tumor types, miR‑1183 indirectly controls the expression of pivotal oncogenic targets, thus influencing proliferation, invasion, and therapeutic resistance in cancer. In parallel, its upregulation in cardiac tissues under both acute and chronic stress conditions suggests a dual role as a biomarker and potential effector in myocardial remodeling. Such multifaceted involvement makes miR‑1183 an attractive candidate for further investigation as both a prognostic marker and therapeutic target in oncology and cardiovascular diseases.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "You Zhou, Xiao Zheng, Bin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non-small cell lung cancer by miR-1183/PDPK1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.11.157"}], "href": "https://doi.org/10.1016/j.bbrc.2018.11.157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30509491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30509491"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Zhang, Hang Zhang, Xudong Zhao "}, {"type": "b", "children": [{"type": "t", "text": "circ_0005273 promotes thyroid carcinoma progression by SOX2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-19-0381"}], "href": "https://doi.org/10.1530/ERC-19-0381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31693489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31693489"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Changle Ji, Linbo Zhu, Lin Fang "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2022.110494"}], "href": "https://doi.org/10.1016/j.cellsig.2022.110494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36241055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36241055"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ni Li, Jiangfang Lian, Sheng Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of Differentially Expressed MicroRNAs in Rheumatic Heart Disease: miR-1183 and miR-1299 as Potential Diagnostic Biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/524519"}], "href": "https://doi.org/10.1155/2015/524519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26539505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26539505"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Natasa Djalinac, Ewald Kolesnik, Heinrich Maechler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23136962"}], "href": "https://doi.org/10.3390/ijms23136962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35805966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35805966"}]}]}]}