MIR1184-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 1184-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‑1184 (miR‑1184) has emerged as a critical regulatory molecule whose expression is variably altered across different diseases. In prostate cancer, elevated levels of miR‑1184 in circulating plasma have been observed, suggesting its potential diagnostic relevance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colon cancer, miR‑1184 is notably down‑regulated; experimental over‑expression studies have demonstrated that miR‑1184 inhibits cell proliferation and promotes apoptosis by directly targeting CSNK2A1, indicating a tumor‑suppressive function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Meanwhile, in colorectal cancer tissues, sponging of miR‑1184 by circ_0128846 results in a reduction of miR‑1184 levels, which in turn elevates AJUBA expression and inactivates Hippo/YAP signaling, thereby contributing to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several other carcinomas, miR‑1184 functions are similarly modulated by circular RNAs. In HER2‑positive breast cancer, circ_0001598 sequesters miR‑1184, relieving its suppression on PD‑L1 and thereby facilitating both tumor growth and resistance to trastuzumab therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In renal cell carcinoma, circSNX6 acts as a molecular sponge for miR‑1184, which normally inhibits glycerophosphocholine phosphodiesterase 1 (GPCPD1); the subsequent up‑regulation of GPCPD1 leads to increased intracellular lysophosphatidic acid levels and the development of sunitinib resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Additionally, in osteosarcoma, a regulatory network involving circ_0000073, miR‑1184, and FADS2 has been proposed to modulate lipid metabolism, a process that can influence tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncology, miR‑1184 also plays protective roles in acute tissue injury. In acute kidney injury models, delivery of miR‑1184 via exosomes from mesenchymal stem cells suppresses the expression of FOXO4, thereby reducing apoptosis, inflammation, and cell cycle dysregulation in cisplatin‑treated renal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Similarly, in hypoxia‑induced injury models of cardiomyocytes, increased expression of circHSPG2 leads to the sequestration of miR‑1184, which normally targets MAP3K2. Restoration of miR‑1184 levels in this context alleviates myocardial injury by repressing MAP3K2‑mediated stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E N Knyazev, K A Fomicheva, D S Mikhailenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-016-3357-7"}], "href": "https://doi.org/10.1007/s10517-016-3357-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27265125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27265125"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuo Chen, Yan Wang, Mingyue Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101625"}], "href": "https://doi.org/10.1016/j.mcp.2020.101625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32619668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32619668"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xu Wang, Yujia Chen, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15590"}], "href": "https://doi.org/10.1111/jcmm.15590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32681581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32681581"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Li Huang, Jing Ma, Min Cui "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12026-021-09237-w"}], "href": "https://doi.org/10.1007/s12026-021-09237-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34559381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34559381"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kang-Bo Huang, Yi-Hui Pan, Guan-Nan Shu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.10.003"}], "href": "https://doi.org/10.1016/j.canlet.2021.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34626691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34626691"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhijing Ren, Shuhui Wang, Bo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0000073 promotes lipid synthesis of osteosarcoma through hsa-miR-1184/ FADS2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2023.110829"}], "href": "https://doi.org/10.1016/j.cellsig.2023.110829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37506860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37506860"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jinshi Zhang, Wenfang He, Danna Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal‑miR‑1184 derived from mesenchymal stem cells alleviates cisplatin‑associated acute kidney injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12435"}], "href": "https://doi.org/10.3892/mmr.2021.12435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34515319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34515319"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Liu Huang, Bingyan Guo, Jie Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stress Chaperones (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12192-023-01328-x"}], "href": "https://doi.org/10.1007/s12192-023-01328-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36810972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36810972"}]}]}]}
Synonyms HSA-MIR-1184, MIR1184, MIRN1184, HSA-MIR-1184-1
NCBI Gene ID 100302111
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Predicted Functions View MIR1184-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR1184-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR1184-1's ARCHS4 Predicted Functions.

Functional Associations

MIR1184-1 has 473 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.

Click the + buttons to view associations for MIR1184-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1184-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR1184-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR1184-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR1184-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR1184-1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR1184-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR1184-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.