{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies indicate that hsa‐miR-1184, also referred to as MIR1184-2, is involved in cancer biology. In patients with prostatic cancer, circulating levels of hsa‐miR-1184 are significantly increased compared to benign hyperplasia, suggesting that its upregulation may be associated with tumor presence or progression and that it might be linked to the regulation of host gene functions encoded within introns. This observation points to a potential role as a biomarker or as a modulator of pathways contributing to prostatic tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In colon cancer, contrasting evidence reveals that miR-1184 is notably down-regulated in both cancer cells and tissues. Functional studies demonstrate that overexpression of miR-1184 suppresses cellular proliferation and enhances apoptotic activity, effects that are mediated by its direct targeting of the CSNK2A1 gene. The reversal of these anti-cancer effects upon CSNK2A1 overexpression further supports a tumor-suppressive role for miR-1184 in colon cancer pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E N Knyazev, K A Fomicheva, D S Mikhailenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-016-3357-7"}], "href": "https://doi.org/10.1007/s10517-016-3357-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27265125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27265125"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuo Chen, Yan Wang, Mingyue Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101625"}], "href": "https://doi.org/10.1016/j.mcp.2020.101625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32619668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32619668"}]}]}]}