{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study of prostatic cancer versus benign hyperplasia, researchers observed an increased expression of miR-1184 in the plasma of prostatic cancer patients. This up-regulation, along with changes in other microRNAs, was discussed in relation to the regulatory functions of the host genes that contain intronic sequences encoding these microRNAs. Such findings suggest that miR-1184 may be linked to oncogenic processes in prostate tissue, potentially interacting with host gene networks that modulate tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colon cancer cells and tissues, miR-1184 was found to be significantly down-regulated compared to normal controls. Functional assays demonstrated that restoring miR-1184 expression inhibited cancer cell proliferation—evidenced by decreased Ki67 expression—and induced apoptosis through the up-regulation of cleaved caspase-3 and down-regulation of Bcl-2. Mechanistically, miR-1184 directly targets CSNK2A1, and its over-expression reverses the tumor-promoting effects mediated by this gene, positioning miR-1184 as a tumor suppressor in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile research on non-coding RNAs extends beyond microRNAs, an investigation into circular RNAs in bladder cancer provides broader context to the intricate RNA regulatory networks present in various malignancies. Although this study focused on circ_0008035 and did not specifically address miR-1184, it underscores the importance of non-coding RNA research in understanding cancer progression and suggests that insights from one class of RNAs may inform the roles of others, including miR-1184."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E N Knyazev, K A Fomicheva, D S Mikhailenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bull Exp Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10517-016-3357-7"}], "href": "https://doi.org/10.1007/s10517-016-3357-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27265125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27265125"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuo Chen, Yan Wang, Mingyue Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101625"}], "href": "https://doi.org/10.1016/j.mcp.2020.101625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32619668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32619668"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yang Fu, Kun Liu, Xi Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol Int (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000527873"}], "href": "https://doi.org/10.1159/000527873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36958293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36958293"}]}]}]}