{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, MIR1185-1 acts as a novel tumor suppressor microRNA that is epigenetically regulated by SIRT1. SIRT1 inhibition leads to enhanced histone acetylation on the MIR1185-1 promoter, increasing its expression. Elevated MIR1185-1 subsequently targets the 3′UTR of the CD24 mRNA, downregulating CD24 expression and thereby reducing cancer stemness properties and tumor growth. This SIRT1–MIR1185-1–CD24 regulatory axis highlights the potential of MIR1185-1 as a therapeutic target in colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of metabolic regulation, MIR1185-1 has been identified as a biomarker linked to weight-loss response. In a study comparing high responders to low responders in a dietary intervention, MIR1185-1 levels were significantly elevated in high responders. Functional assays demonstrated that MIR1185-1 binds to the 3′UTR of GSK3B, leading to diminished expression of this proinflammatory gene, suggesting a role for MIR1185-1 in modulating inflammatory processes associated with metabolic improvement upon weight loss."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, MIR1185-1 is implicated in the neurobiology of schizophrenia through its posttranscriptional regulation of glial cell line-derived neurotrophic factor (GDNF). A risk-associated single nucleotide polymorphism (SNP) in the 3′UTR of the GDNF gene creates a binding site for MIR1185-1, and in vitro studies have shown that this microRNA represses reporter activity in a dose-dependent manner when the risk allele is present. This finding suggests that MIR1185-1 may contribute to the downregulation of GDNF expression in patients with schizophrenia, potentially impacting dopaminergic neuron survival and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Teh-Wei Wang, Edward Chern, Chao-Wei Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SIRT1-Mediated Expression of CD24 and Epigenetic Suppression of Novel Tumor Suppressor miR-1185-1 Increases Colorectal Cancer Stemness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-19-3188"}], "href": "https://doi.org/10.1158/0008-5472.CAN-19-3188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33046442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33046442"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marcos Garcia-Lacarte, Maria L Mansego, M Angeles Zulet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-1185-1 and miR-548q Are Biomarkers of Response to Weight Loss and Regulate the Expression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "GSK3B"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8121548"}], "href": "https://doi.org/10.3390/cells8121548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31801236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31801236"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gergely Keszler, Bálint Vékony, Zsuzsanna Elek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-Mediated Suppression of Glial Cell Line-Derived Neurotrophic Factor Expression Is Modulated by a Schizophrenia-Associated Non-Coding Polymorphism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms25084477"}], "href": "https://doi.org/10.3390/ijms25084477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38674063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38674063"}]}]}]}