{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into serum microRNAs as diagnostic biomarkers have highlighted MIR1185-2 as a potentially valuable candidate in improving the specificity of prostate cancer screening. Although traditionally prostate‐specific antigen (PSA) testing suffers from a high false‐positive rate, the inclusion of MIR1185-2 among circulating miRNAs may help refine early detection approaches, thereby reducing unnecessary biopsies and optimizing clinical decision‐making in patients suspected of harboring prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDisruptions in vascular homeostasis underlie the progression of atherosclerosis, and miRNAs are emerging as pivotal modulators of this complex process. In particular, MIR1185-2 is implicated in regulating key pathways associated with arterial stiffness and endothelial apoptosis. Its modulation might influence the underlying inflammatory and apoptotic responses that drive the atherosclerotic process, as suggested by studies examining both stiffness‐related changes and endothelial injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nEmerging evidence also points to a role for MIR1185-2 in breast tumorigenesis. In the context of breast cancer, dysregulation of oncogenic factors such as GOLPH3L has been linked to adverse prognoses. Here, MIR1185-2 may interact with or regulate such factors, thereby contributing to tumor initiation or progression. Further exploration of MIR1185-2’s function in this setting could offer insights into novel therapeutic routes for breast cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fumihiko Urabe, Juntaro Matsuzaki, Yusuke Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Large-scale Circulating microRNA Profiling for the Liquid Biopsy of Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-18-2849"}], "href": "https://doi.org/10.1158/1078-0432.CCR-18-2849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30808771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30808771"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haoyuan Deng, Zhenfeng Song, Huan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1185 Promotes Arterial Stiffness though Modulating VCAM-1 and E-Selectin Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000475576"}], "href": "https://doi.org/10.1159/000475576"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28441665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28441665"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Haoyuan Deng, Xia Chu, Zhenfeng Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000475571"}], "href": "https://doi.org/10.1159/000475571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28441650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28441650"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Youqin Xu, Wancheng Chen, Jing Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-1185-2-3p-GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01767-9"}], "href": "https://doi.org/10.1186/s13046-020-01767-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33509226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33509226"}]}]}]}